Literature DB >> 24914436

Integrin β3 links therapy resistance and cancer stem cell properties.

Nagarajan Kannan, Long V Nguyen, Connie J Eaves.   

Abstract

Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin α(v)β₃ expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

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Year:  2014        PMID： 24914436     DOI： 10.1038/ncb2960

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

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  8 in total

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