Carla Bastida1, Maria Antonia Also2, Juan Manuel Pericas2, Emili Letang3, Montse Tuset4, Josep Maria Miró2. 1. Servicio de Farmacia, Hospital Clínic, Barcelona, España. Electronic address: cbastida@clinic.ub.es. 2. Servicio de Enfermedades Infecciosas, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Barcelona, España. 3. Swiss Tropical and Public Health Institute (Swiss TPH), Basilea, Suiza; Centre de Recerca en Salut Internacional de Barcelona (CRESIB), Hospital Clínic, Universitat de Barcelona, Barcelona, España. 4. Servicio de Farmacia, Hospital Clínic, Barcelona, España.
Abstract
INTRODUCTION: Drugs like statins may induce rhabdomyolysis. Simvastatin and lovastatin have a high hepatic metabolism and their potential toxicity could be increased by interactions with other drugs that reduce their metabolism. PATIENTS AND METHODS: A case-report is presented of an HIV-infected patient treated with antiretroviral drugs who developed a rhabdomyolysis-induced renal failure and liver toxicity when simvastatin was substituted for atorvastatin. A literature review is also presented. RESULTS: The patient required hospital admission and showed a favorable response after hydration and urine alkalinization. There were 4 additional cases published of which there was one death. CONCLUSIONS: Drug-drug interactions can increase the risk of statin induced rhabdomyolysis. In order to evaluate them properly, physicians at all levels of clinical care should be aware of all drugs prescribed to their patients and the contraindicated combinations.
INTRODUCTION: Drugs like statins may induce rhabdomyolysis. Simvastatin and lovastatin have a high hepatic metabolism and their potential toxicity could be increased by interactions with other drugs that reduce their metabolism. PATIENTS AND METHODS: A case-report is presented of an HIV-infectedpatient treated with antiretroviral drugs who developed a rhabdomyolysis-induced renal failure and liver toxicity when simvastatin was substituted for atorvastatin. A literature review is also presented. RESULTS: The patient required hospital admission and showed a favorable response after hydration and urine alkalinization. There were 4 additional cases published of which there was one death. CONCLUSIONS: Drug-drug interactions can increase the risk of statin induced rhabdomyolysis. In order to evaluate them properly, physicians at all levels of clinical care should be aware of all drugs prescribed to their patients and the contraindicated combinations.
Authors: Payal Kohli; Peter Ganz; Yifei Ma; Rebecca Scherzer; Sophia Hur; Bernard Weigel; Carl Grunfeld; Steven Deeks; Scott Wasserman; Rob Scott; Priscilla Y Hsue Journal: J Am Heart Assoc Date: 2016-04-29 Impact factor: 5.501
Authors: Gabriella d'Ettorre; Giancarlo Ceccarelli; Paolo Pavone; Pietro Vittozzi; Gabriella De Girolamo; Ivan Schietroma; Sara Serafino; Noemi Giustini; Vincenzo Vullo Journal: AIDS Res Ther Date: 2016-04-27 Impact factor: 2.250