Paul A Dennis1, Christi S Ulmer2, Patrick S Calhoun3, Andrew Sherwood4, Lana L Watkins4, Michelle F Dennis5, Jean C Beckham6. 1. Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA. 2. Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA; Veterans Affairs Center for Health Services Research in Primary Care, Durham, NC, 27705, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA. 3. Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA; Veterans Affairs Mid-Atlantic Region Mental Illness Research, Education, and Clinical Center, Durham, NC 27705, USA; Veterans Affairs Center for Health Services Research in Primary Care, Durham, NC, 27705, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA. 4. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA. 5. Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA. 6. Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA; Veterans Affairs Mid-Atlantic Region Mental Illness Research, Education, and Clinical Center, Durham, NC 27705, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA. Electronic address: jean.beckham@va.gov.
Abstract
OBJECTIVES: Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia. METHODS: To test this hypothesis, serum lipid levels were collected from 220 young adults (18-39 years old), 103 of whom were diagnosed with PTSD. RESULTS: PTSD and associated depressive symptoms were negatively related to high-density lipoprotein cholesterol (HDL-C), p=.04, and positively related to triglyceride (TG) levels, p=.04. Both associations were mediated by cigarette consumption and poor sleep quality, the latter of which accounted for 83% and 93% of the effect of PTSD and depression on HDL-C and TG, respectively. CONCLUSIONS: These results complement recent findings highlighting the prominence of health behaviors in linking PTSD with cardiovascular risk. Published by Elsevier Inc.
OBJECTIVES:Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia. METHODS: To test this hypothesis, serum lipid levels were collected from 220 young adults (18-39 years old), 103 of whom were diagnosed with PTSD. RESULTS:PTSD and associated depressive symptoms were negatively related to high-density lipoprotein cholesterol (HDL-C), p=.04, and positively related to triglyceride (TG) levels, p=.04. Both associations were mediated by cigarette consumption and poor sleep quality, the latter of which accounted for 83% and 93% of the effect of PTSD and depression on HDL-C and TG, respectively. CONCLUSIONS: These results complement recent findings highlighting the prominence of health behaviors in linking PTSD with cardiovascular risk. Published by Elsevier Inc.
Authors: K Chin; K Shimizu; T Nakamura; N Narai; H Masuzaki; Y Ogawa; M Mishima; T Nakamura; K Nakao; M Ohi Journal: Circulation Date: 1999-08-17 Impact factor: 29.690
Authors: Ania E Oddone; Paul A Dennis; Patrick S Calhoun; Lana L Watkins; Andrew Sherwood; Eric A Dedert; Kimberly T Green; Jacob N Stein; Michelle F Dennis; Jean C Beckham Journal: Psychol Trauma Date: 2014-11-10
Authors: Arianne K B van Reedt Dortland; Sophie A Vreeburg; Erik J Giltay; Carmilla M M Licht; Nicole Vogelzangs; Tineke van Veen; Eco J C de Geus; Brenda W J H Penninx; Frans G Zitman Journal: Psychoneuroendocrinology Date: 2012-06-18 Impact factor: 4.905
Authors: Paul A Dennis; Lana L Watkins; Patrick S Calhoun; Ania Oddone; Andrew Sherwood; Michelle F Dennis; Michelle B Rissling; Jean C Beckham Journal: Psychosom Med Date: 2014-10 Impact factor: 4.312
Authors: Jeffrey L Kibler; Mindy Ma; Mischa Tursich; Lydia Malcolm; Maria M Llabre; Rachel Greenbarg; Steven N Gold; Jean C Beckham Journal: J Affect Disord Date: 2018-08-07 Impact factor: 4.839
Authors: Paul A Dennis; Nathan A Kimbrel; Andrew Sherwood; Patrick S Calhoun; Lana L Watkins; Michelle F Dennis; Jean C Beckham Journal: Psychosom Med Date: 2017-06 Impact factor: 4.312
Authors: Barton W Palmer; Catherine Shir; Hang Chang; Mallory Mulvaney; Joshua M H Hall; I-Wei Shu; Hua Jin; James B Lohr Journal: Int J Ment Health Date: 2021-08-25
Authors: Michelle B Rissling; Paul A Dennis; Lana L Watkins; Patrick S Calhoun; Michelle F Dennis; Jean C Beckham; Junichiro Hayano; Christi S Ulmer Journal: J Trauma Stress Date: 2016-09-07
Authors: Paul A Dennis; J Brice Weinberg; Patrick S Calhoun; Lana L Watkins; Andrew Sherwood; Michelle F Dennis; Jean C Beckham Journal: J Psychosom Res Date: 2016-02-26 Impact factor: 3.006
Authors: Paul A Dennis; Julia M Neal; Emili Travis; Lana L Watkins; Patrick S Calhoun; Michelle F Dennis; Jean C Beckham Journal: J Psychophysiol Date: 2018-07-18 Impact factor: 1.333
Authors: Matthias Michal; Jörg Wiltink; Yvonne Kirschner; Astrid Schneider; Philipp S Wild; Thomas Münzel; Maria Blettner; Andreas Schulz; Karl Lackner; Norbert Pfeiffer; Stefan Blankenberg; Regine Tschan; Inka Tuin; Manfred E Beutel Journal: PLoS One Date: 2014-08-05 Impact factor: 3.240