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Literature DB >> 24912984

Macromolecular complexes at active zones: integrated nano-machineries for neurotransmitter release.

Abstract

The release of neurotransmitters from synaptic vesicles exocytosing at presynaptic nerve terminals is a critical event in the initiation of synaptic transmission. This event occurs at specialized sites known as active zones. The task of faithfully executing various steps in the process is undertaken by careful orchestration of overlapping sets of molecular nano-machineries upon a core macromolecular scaffold situated at active zones. However, their composition remains incompletely elucidated. This review provides an overview of the role of the active zone in mediating neurotransmitter release and summarizes the recent progress using neuroproteomic approaches to decipher their composition. Key proteins of these nano-machineries are highlighted.

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Year: 2014 PMID： 24912984 DOI： 10.1007/s00018-014-1657-5

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

163 in total

Review 1. RIM proteins and their role in synapse function.

Authors: Tobias Mittelstaedt; Elena Alvaréz-Baron; Susanne Schoch
Journal: Biol Chem Date: 2010-06 Impact factor: 3.915

Review 2. SNAREs--engines for membrane fusion.

Authors: Reinhard Jahn; Richard H Scheller
Journal: Nat Rev Mol Cell Biol Date: 2006-08-16 Impact factor: 94.444

3. Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channel.

Authors: Shigeki Kiyonaka; Hiroshi Nakajima; Yoshinori Takada; Yamato Hida; Toshinori Yoshioka; Akari Hagiwara; Isao Kitajima; Yasuo Mori; Toshihisa Ohtsuka
Journal: J Biochem Date: 2012-05-09 Impact factor: 3.387

4. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.

Authors: Janina Boyken; Mads Grønborg; Dietmar Riedel; Henning Urlaub; Reinhard Jahn; John Jia En Chua
Journal: Neuron Date: 2013-04-24 Impact factor: 17.173

5. The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina.

Authors: Oliver Dick; Susanne tom Dieck; Wilko Detlef Altrock; Josef Ammermüller; Reto Weiler; Craig Curtis Garner; Eckart Dieter Gundelfinger; Johann Helmut Brandstätter
Journal: Neuron Date: 2003-03-06 Impact factor: 17.173

6. Isolation of synaptic junctional complexes from rat brain.

Authors: G A Davis; F E Bloom
Journal: Brain Res Date: 1973-11-09 Impact factor: 3.252

7. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

Authors: Shigeki Kiyonaka; Minoru Wakamori; Takafumi Miki; Yoshitsugu Uriu; Mio Nonaka; Haruhiko Bito; Aaron M Beedle; Emiko Mori; Yuji Hara; Michel De Waard; Motoi Kanagawa; Makoto Itakura; Masami Takahashi; Kevin P Campbell; Yasuo Mori
Journal: Nat Neurosci Date: 2007-05-13 Impact factor: 24.884

8. Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.

Authors: Cong Ma; Wei Li; Yibin Xu; Josep Rizo
Journal: Nat Struct Mol Biol Date: 2011-04-17 Impact factor: 15.369

9. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.

Authors: Thomas M Wishart; Timothy M Rooney; Douglas J Lamont; Ann K Wright; A Jennifer Morton; Mandy Jackson; Marc R Freeman; Thomas H Gillingwater
Journal: PLoS Genet Date: 2012-08-30 Impact factor: 5.917

10. Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.

Authors: Toshihisa Ohtsuka; Etsuko Takao-Rikitsu; Eiji Inoue; Marie Inoue; Masakazu Takeuchi; Kaho Matsubara; Maki Deguchi-Tawarada; Keiko Satoh; Koji Morimoto; Hiroyuki Nakanishi; Yoshimi Takai
Journal: J Cell Biol Date: 2002-08-05 Impact factor: 10.539

6 in total

Macromolecular complexes at active zones: integrated nano-machineries for neurotransmitter release.

Review 1. RIM proteins and their role in synapse function.

Review 2. SNAREs--engines for membrane fusion.

3. Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channel.

4. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.

5. The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina.

6. Isolation of synaptic junctional complexes from rat brain.

7. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

8. Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.

9. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.

10. Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.

1. ER arrival sites for COPI vesicles localize to hotspots of membrane trafficking.

2. Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation.

Review 3. Functions of Rab Proteins at Presynaptic Sites.

Review 4. The Roles of Microtubule-Based Transport at Presynaptic Nerve Terminals.

Review 5. The axonal cytoskeleton: from organization to function.

6. Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins.