Haiping Liu1, Jianfeng Wu2, Haiyu Wang1, Lianbing Sheng1, Ning Tang1, Yunfei Li1, Tianyu Hao3. 1. Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China. 2. The Second Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China. 3. Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China schuhty@126.com.
Abstract
BACKGROUND: Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. METHODS: Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method. RESULTS: Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P < 0.001), systolic blood pressure (P < 0.05) and homeostasis model assessment of insulin resistance (P < 0.001). CONCLUSION: Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.
BACKGROUND: Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. METHODS: Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method. RESULTS:Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P < 0.001), systolic blood pressure (P < 0.05) and homeostasis model assessment of insulin resistance (P < 0.001). CONCLUSION: Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.