Literature DB >> 2491263

The fibroblast growth factor family: structural and biological properties.

M Klagsbrun1.   

Abstract

This article summarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation, motility and differentiation. They are also potent angiogenesis factors in vivo. Some of the important biological characteristics of bFGF and aFGF discussed in the review include the affinity of bFGF and aFGF for heparin, their lack of secretion in culture and their association with extracellular matrix. Recently, several oncogenes, 40-50% homologous in sequence to bFGF and aFGF have been identified. These include int-2, hst, K-fgf and FGF-5. The structural and biological properties of these FGF-related oncogenes are also discussed.

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Year:  1989        PMID： 2491263     DOI： 10.1016/0955-2235(89)90012-4

Source DB:  PubMed          Journal:  Prog Growth Factor Res        ISSN： 0955-2235


  57 in total

Review 1.  Arteriogenesis: mechanisms and modulation of collateral artery development.

Authors:  N Van Royen; J J Piek; W Schaper; C Bode; I Buschmann
Journal:  J Nucl Cardiol       Date:  2001 Nov-Dec       Impact factor: 5.952

2.  Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas.

Authors:  S La Rosa; F Sessa; L Colombo; M G Tibiletti; D Furlan; C Capella
Journal:  J Clin Pathol       Date:  2001-01       Impact factor: 3.411

3.  Isolation and characterization of a macrophage-derived heparin-binding growth factor.

Authors:  G Besner; S Higashiyama; M Klagsbrun
Journal:  Cell Regul       Date:  1990-10

4.  Anti-angiogenesis as a new concept for the therapy of neovascular diseases.

Authors:  L Schweigerer
Journal:  Klin Wochenschr       Date:  1991-07-22

Review 5.  Modes of FGF release in vivo and in vitro.

Authors:  P A D'Amore
Journal:  Cancer Metastasis Rev       Date:  1990-11       Impact factor: 9.264

6.  The placenta growth factor gene of the mouse.

Authors:  T DiPalma; M Tucci; G Russo; D Maglione; C T Lago; A Romano; S Saccone; G Della Valle; L De Gregorio; T A Dragani; G Viglietto; M G Persico
Journal:  Mamm Genome       Date:  1996-01       Impact factor: 2.957

7.  Expression of fibroblast growth factor binding protein HBp17 in normal and tumor cells.

Authors:  T Okamoto; Y Tanaka; M Kan; A Sakamoto; K Takada; J D Sato
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-02       Impact factor: 2.416

8.  A novel physiological function for platelet-derived growth factor-BB in rat dermis.

Authors:  S A Rodt; K Ahlén; A Berg; K Rubin; R K Reed
Journal:  J Physiol       Date:  1996-08-15       Impact factor: 5.182

9.  Culture density regulates both the cholinergic phenotype and the expression of the CNTF receptor in P19 neurons.

Authors:  D Parnas; M Linial
Journal:  J Mol Neurosci       Date:  1997-04       Impact factor: 3.444

10.  High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains.

Authors:  H G Cheon; W J LaRochelle; D P Bottaro; W H Burgess; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205
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