Literature DB >> 2491254

The gene structure of the insulin-like growth factor family.

J S Sussenbach1.   

Abstract

The insulin-like growth factors (IGF) constitute a family of proteins with insulin-like and growth-stimulating properties. The best characterized members of this family are IGF-I, a protein of 70 amino acids which plays an important role in post-natal growth, and IGF-II, a 67 amino acid protein which is most likely involved in fetal development. The gene structure of IGF-II has been elucidated for the human and the rat and shows extensive interspecies homologies. The gene structure of IGF-I has only partially been established. A striking feature of the IGF genes is that they are controlled by multiple promoters which are expressed in a tissue-specific and development-dependent way.

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Year:  1989        PMID： 2491254     DOI： 10.1016/0955-2235(89)90040-9

Source DB:  PubMed          Journal:  Prog Growth Factor Res        ISSN： 0955-2235


  19 in total

1.  Nucleotide sequence of a porcine insulin-like growth factor II cDNA.

Authors:  I R Catchpole; W Engström
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

Review 2.  Insulin-like growth factors in the gastrointestinal tract and liver.

Authors:  John F Kuemmerle
Journal:  Endocrinol Metab Clin North Am       Date:  2012-05-15       Impact factor: 4.741

Review 3.  Molecular biology of the insulin-like growth factors. Relevance to nervous system function.

Authors:  J E Hepler; P K Lund
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

4.  A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.

Authors:  J Nielsen; J Christiansen; J Lykke-Andersen; A H Johnsen; U M Wewer; F C Nielsen
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

5.  Identification of a novel transcription unit in the human insulin-like growth factor-II gene.

Authors:  K Ikejiri; T Wasada; K Haruki; N Hizuka; Y Hirata; M Yamamoto
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

6.  mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.

Authors:  Ning Dai; Jan Christiansen; Finn C Nielsen; Joseph Avruch
Journal:  Genes Dev       Date:  2013-02-01       Impact factor: 11.361

7.  Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex.

Authors:  A Caricasole; A Ward
Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971

8.  Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3.

Authors:  Julian C Lui; Jeffrey Baron
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-25       Impact factor: 11.205

9.  Molecular analysis of patients with Wiedemann-Beckwith syndrome. I. Gene dosage on the short arm of chromosome 11.

Authors:  A Nyström; W Engström; J Cheetham; P N Schofield
Journal:  Eur J Pediatr       Date:  1992-07       Impact factor: 3.183

10.  Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching.

Authors:  Y Zhang; T Shields; T Crenshaw; Y Hao; T Moulton; B Tycko
Journal:  Am J Hum Genet       Date:  1993-07       Impact factor: 11.025
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