| Literature DB >> 24912164 |
Theodore D Satterthwaite1, Russell T Shinohara2, Daniel H Wolf3, Ryan D Hopson4, Mark A Elliott5, Simon N Vandekar4, Kosha Ruparel4, Monica E Calkins4, David R Roalf4, Efstathios D Gennatas4, Chad Jackson4, Guray Erus6, Karthik Prabhakaran4, Christos Davatzikos6, John A Detre7, Hakon Hakonarson8, Ruben C Gur9, Raquel E Gur10.
Abstract
Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.Entities:
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Year: 2014 PMID： 24912164 PMCID： PMC4060665 DOI： 10.1073/pnas.1400178111
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205