BACKGROUND: The studies aimed to evaluate the changes in cysteine sulfur metabolism in erythrocytes of end-stage renal failure (ESRF) patients treated with continuous ambulatory peritoneal dialysis (CAPD) caused by a one-month lipoate (LA) supplementation at a daily dose of 600 mg. METHODS: The level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of CAPD patients and in the control group. RESULTS: The sulfane sulfur level in erythrocytes of CAPD patients did not differ compared with healthy volunteers but LA supplementation increased the reactive sulfur concentration. LA elevated also cystathionase activity. CONCLUSIONS: LA supplementation in ESRF patients treated with CAPD increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties.
BACKGROUND: The studies aimed to evaluate the changes in cysteinesulfur metabolism in erythrocytes of end-stage renal failure (ESRF) patients treated with continuous ambulatory peritoneal dialysis (CAPD) caused by a one-month lipoate (LA) supplementation at a daily dose of 600 mg. METHODS: The level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of CAPD patients and in the control group. RESULTS: The sulfane sulfur level in erythrocytes of CAPD patients did not differ compared with healthy volunteers but LA supplementation increased the reactive sulfur concentration. LA elevated also cystathionase activity. CONCLUSIONS: LA supplementation in ESRF patients treated with CAPD increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties.