H Han1, C Han1, S Huang2, J Guo3, X Zhuang4. 1. Department of Radiology, The First Affiliated Hospital of Xiamen University, Fujian, China. 2. Department of Cardiology, The First Affiliated Hospital of Xiamen University, Fujian, China. 3. Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Fujian, China. 4. Department of Radiology, The First Affiliated Hospital of Xiamen University, Fujian, China. Electronic address: zhuangxiongjievip@163.com.
Abstract
AIM: To investigate the utility of diffusion-weighted (DW) magnetic resonance imaging (MRI) with a high b-value (b = 3000 s/mm(2)) compared with standard b-value (b = 1000 s/mm(2)) DW imaging in patients with primary central nervous system lymphoma (PCNSL). MATERIALS AND METHODS: High and standard b-value (b = 3000 and 1000 s/mm(2), respectively) DW images were acquired in 15 patients with PCNSL. The number and location of the lesions were assessed. MRI signal intensities (SIs), signal-to-noise ratios (SNRs), contrast-to-noise ratios (CNRs), contrast ratios (CRs), and apparent diffusion coefficients (ADCs) of the lesions and normal parenchyma were measured. RESULTS: Thirty-two lesions in 15 patients were revealed. Twenty-seven of the lesions were hyperintense at DW MRI with high and standard b-values; high b-value images revealed five additional lesions. Lesions were also more conspicuous at high b-value (b = 3000 s/mm(2)) DW MRI compared to standard b-value images (b = 1000 s/mm(2)). SNR, CNR, and ADC values in lesions and normal parenchyma were lower in the b = 3000 s/mm(2) images compared to the b = 1000 s/mm(2) images (SNR: 250.7 ± 124.7 versus 112.3 ± 68.7; CNR: 83.4 ± 74.7 versus 59.6 ± 60.4, b = 1000 and 3000 s/mm(2), respectively). The CR was significantly greater in the b = 3000 s/mm(2) images compared to the b = 1000 s/mm(2) images (CR: 0.28 ± 0.13 versus 0.18 ± 0.10). CONCLUSIONS: Although quantitative analyses revealed higher SI, SNR, and CNR values in standard b-value (b = 1000 s/mm(2)) DW images, higher b-value imaging could be beneficial for detecting additional lesions and improving the contrast between lesions and normal tissue in patients with PCNSL.
AIM: To investigate the utility of diffusion-weighted (DW) magnetic resonance imaging (MRI) with a high b-value (b = 3000 s/mm(2)) compared with standard b-value (b = 1000 s/mm(2)) DW imaging in patients with primary central nervous system lymphoma (PCNSL). MATERIALS AND METHODS: High and standard b-value (b = 3000 and 1000 s/mm(2), respectively) DW images were acquired in 15 patients with PCNSL. The number and location of the lesions were assessed. MRI signal intensities (SIs), signal-to-noise ratios (SNRs), contrast-to-noise ratios (CNRs), contrast ratios (CRs), and apparent diffusion coefficients (ADCs) of the lesions and normal parenchyma were measured. RESULTS: Thirty-two lesions in 15 patients were revealed. Twenty-seven of the lesions were hyperintense at DW MRI with high and standard b-values; high b-value images revealed five additional lesions. Lesions were also more conspicuous at high b-value (b = 3000 s/mm(2)) DW MRI compared to standard b-value images (b = 1000 s/mm(2)). SNR, CNR, and ADC values in lesions and normal parenchyma were lower in the b = 3000 s/mm(2) images compared to the b = 1000 s/mm(2) images (SNR: 250.7 ± 124.7 versus 112.3 ± 68.7; CNR: 83.4 ± 74.7 versus 59.6 ± 60.4, b = 1000 and 3000 s/mm(2), respectively). The CR was significantly greater in the b = 3000 s/mm(2) images compared to the b = 1000 s/mm(2) images (CR: 0.28 ± 0.13 versus 0.18 ± 0.10). CONCLUSIONS: Although quantitative analyses revealed higher SI, SNR, and CNR values in standard b-value (b = 1000 s/mm(2)) DW images, higher b-value imaging could be beneficial for detecting additional lesions and improving the contrast between lesions and normal tissue in patients with PCNSL.