Guo-Wei Zhang1, Jian-Hua Lin2, Jian-Ping Qian2, Jie Zhou2. 1. Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, China. Electronic address: guoweizhang77@hotmail.com. 2. Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, China.
Abstract
OBJECTIVES: To identify the risk factors of bile leakage, with different severity, based on Clavien-Dindo complication classification system. MATERIALS AND METHODS: A retrospective analysis of 943 eligible patients was performed. Sixty-eight patients, with bile leakage, were divided into 2 groups: mild bile leakage (grades I, II, n = 41) and severe bile leakage (grades III, IV, V, n = 27). Twenty-five potential factors were analyzed, by multivariate regression analyses, to identify independent risk factors of bile leakage. RESULTS: The independent risk factors of bile leakage, for the entire cohort, included attacks of acute cholangitis within 1 month, associated biliary-enteric anastomosis (BEA), associated hepatectomy and previous biliary surgery. The independent risk factors for patients with mild bile leakage were attacks of acute cholangitis within 1 month, associated hepatectomy, and a history of previous biliary surgery. Similarly, the independent risk factors for patients with severe bile leakage were attacks of acute cholangitis within 1 month, associated hepatectomy, and associated BEA. CONCLUSIONS: Risk factors for mild and severe postoperative bile leakage, in bile duct stones, were different.
OBJECTIVES: To identify the risk factors of bile leakage, with different severity, based on Clavien-Dindo complication classification system. MATERIALS AND METHODS: A retrospective analysis of 943 eligible patients was performed. Sixty-eight patients, with bile leakage, were divided into 2 groups: mild bile leakage (grades I, II, n = 41) and severe bile leakage (grades III, IV, V, n = 27). Twenty-five potential factors were analyzed, by multivariate regression analyses, to identify independent risk factors of bile leakage. RESULTS: The independent risk factors of bile leakage, for the entire cohort, included attacks of acute cholangitis within 1 month, associated biliary-enteric anastomosis (BEA), associated hepatectomy and previous biliary surgery. The independent risk factors for patients with mild bile leakage were attacks of acute cholangitis within 1 month, associated hepatectomy, and a history of previous biliary surgery. Similarly, the independent risk factors for patients with severe bile leakage were attacks of acute cholangitis within 1 month, associated hepatectomy, and associated BEA. CONCLUSIONS: Risk factors for mild and severe postoperative bile leakage, in bile duct stones, were different.
Authors: Jaram Lee; Ook Song; Hyeong-Min Park; Soo Young Lee; Chang Hyun Kim; Hyeong Rok Kim Journal: Medicine (Baltimore) Date: 2021-11-19 Impact factor: 1.889