Lidia Yileng Tay1, Janaina Habib Jorge2, Daniel Rodrigo Herrera3, Nara Hellen Campanha1, Brenda Paula Gomes3, Fabio Andre Dos Santos1. 1. Department of Dentistry, Ponta Grossa State University (UEPG), Ponta Grossa, Paraná, Brazil. 2. Department of Dental Materials and Prosthodontics, Araraquara Dental School, UNESP - Univ. Estadual Paulista, Araraquara, São Paulo, Brazil. Electronic address: Janainahj@bol.com.br. 3. Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Abstract
OBJECTIVE: The aim of this clinical study was to determine the efficacy of Uncaria tomentosa (cat's claw) against denture stomatitis (DS). STUDY DESIGN:Fifty patients with DS were randomly assigned into 3 groups to receive 2% miconazole, placebo, or 2% U tomentosa gel. DS level was recorded immediately, after 1 week of treatment, and 1 week after treatment. The clinical effectiveness of each treatment was measured using Newton's criteria. Mycologic samples from palatal mucosa and prosthesis were obtained to determinate colony forming units per milliliter (CFU/mL) and fungal identification at each evaluation period. RESULTS: Candida species were identified with HiCrome Candida and API 20C AUX biochemical test. DS severity decreased in all groups (P < .05). A significant reduction in number of CFU/mL after 1 week (P < .05) was observed for all groups and remained after 14 days (P > .05). C albicans was the most prevalent microorganism before treatment, followed by C tropicalis, C glabrata, and C krusei, regardless of the group and time evaluated. U tomentosa gel had the same effect as 2% miconazole gel. CONCLUSIONS: U tomentosa gel is an effective topical adjuvant treatment for denture stomatitis.
RCT Entities:
OBJECTIVE: The aim of this clinical study was to determine the efficacy of Uncaria tomentosa (cat's claw) against denture stomatitis (DS). STUDY DESIGN: Fifty patients with DS were randomly assigned into 3 groups to receive 2% miconazole, placebo, or 2% U tomentosa gel. DS level was recorded immediately, after 1 week of treatment, and 1 week after treatment. The clinical effectiveness of each treatment was measured using Newton's criteria. Mycologic samples from palatal mucosa and prosthesis were obtained to determinate colony forming units per milliliter (CFU/mL) and fungal identification at each evaluation period. RESULTS: Candida species were identified with HiCrome Candida and API 20C AUX biochemical test. DS severity decreased in all groups (P < .05). A significant reduction in number of CFU/mL after 1 week (P < .05) was observed for all groups and remained after 14 days (P > .05). C albicans was the most prevalent microorganism before treatment, followed by C tropicalis, C glabrata, and C krusei, regardless of the group and time evaluated. U tomentosa gel had the same effect as 2% miconazole gel. CONCLUSIONS: U tomentosa gel is an effective topical adjuvant treatment for denture stomatitis.
Authors: Floriana D'Angeli; Giuseppe Antonio Malfa; Adriana Garozzo; Giovanni Li Volti; Carlo Genovese; Aldo Stivala; Daria Nicolosi; Francesco Attanasio; Francesco Bellia; Simone Ronsisvalle; Rosaria Acquaviva Journal: Antibiotics (Basel) Date: 2021-02-04
Authors: Mario Dioguardi; Francesca Spirito; Diego Sovereto; Andrea Ballini; Mario Alovisi; Lorenzo Lo Muzio Journal: J Clin Med Date: 2022-08-26 Impact factor: 4.964