Literature DB >> 24908247

Endothelial function in hypertensive obese patients: 1 year after surgically induced weight loss.

L Flores1, I Núñez, J Vidal, S Rueda, J Viaplana, L Rodríguez, E Esmatjes.   

Abstract

The aim of this study was to describe the effect of surgically induced weight loss on vascular function measured by flow-mediated dilatation (FMD) in hypertensive obese patients. This prospective study included 33 patients (78 % females, mean age 53 (9) years) undergoing bariatric surgery (BS). Before and 12 months postoperatively, the BMI, 24-h ambulatory BP, high-sensitivity C-reactive protein (hs-CRP), leptin, homeostasis model assessment (HOMA IR), and abdominal fat were measured. Endothelial function was assessed by FMD. After BS, the excess body weight loss was 71 %; the 24-h [systolic 18(11)//diastolic 7(7) mmHg] BP values, hs-CRP, leptin, HOMA, and abdominal fat significantly decreased, with no changes in endothelial function. Weight loss achieved by BS was associated with a significant improvement in BP and metabolic and inflammation parameters, but FMD did not improve.

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Year:  2014        PMID： 24908247     DOI： 10.1007/s11695-014-1328-5

Source DB:  PubMed          Journal:  Obes Surg        ISSN： 0960-8923            Impact factor:   4.129


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