Literature DB >> 24907564

Role of soluble adenylyl cyclase in mitochondria.

Federica Valsecchi1, Csaba Konrad1, Giovanni Manfredi2.   

Abstract

The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO(3)(-)) and calcium (Ca²⁺) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Mitochondria; PKA; Protein phosphorylation; cAMP; sAC

Mesh：

Substances：

Year:  2014        PMID： 24907564      PMCID： PMC4257896          DOI： 10.1016/j.bbadis.2014.05.035

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  84 in total

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