Shen-Shong Chang1, Hsiao-Yun Hu2. 1. Division of Gastroenterology, Taipei City Hospital Yang-Ming Branch, Taipei, Taiwan, ROC; Department of Internal Medicine, Taipei City Hospital Yang-Ming Branch, Taipei, Taiwan, ROC; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. 2. Institute of Public Health and Department of Public Health, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan, ROC. Electronic address: hyhu@ym.edu.tw.
Abstract
BACKGROUND: Distinguishing the rates of Helicobacter pylori infection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical. METHODS: We first stratified the original 1 million study population according to CKD or ESRD. We retrospectively investigated the incidence of H. pylori infection in PUD patients with or without CKD or ESRD between 2000 and 2008 in a nationwide, population-based cohort using data from the Taiwan National Health Insurance Research Database. The comparison cohort consisted of PUD patients without CKD. A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals, to determine whether the occurrence of H. pylori infection in CKD or ESRD patients with PUD differed from that of PUD patients without CKD. RESULTS: Among the CKD patients, 261 patients had H. pylori-positive and 185 H. pylori-negative peptic ulcers. Among the ESRD patients, 81 had H. pylori-positive and 63 H. pylori-negative peptic ulcers. Among the non-CKD control patients, 1658 patients had H. pylori-positive and 702 H. pylori-negative peptic ulcers. Our results revealed a lower H. pylori infection rate in CKD (OR = 0.64, p < 0.001) and ESRD (OR = 0.54, p = 0.001) patients with PUD than in PUD patients without CKD. CONCLUSION: The H. pylori infection rate is lower in PUD patients with CKD and ESRD than in those without CKD.
BACKGROUND: Distinguishing the rates of Helicobacter pyloriinfection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical. METHODS: We first stratified the original 1 million study population according to CKD or ESRD. We retrospectively investigated the incidence of H. pyloriinfection in PUD patients with or without CKD or ESRD between 2000 and 2008 in a nationwide, population-based cohort using data from the Taiwan National Health Insurance Research Database. The comparison cohort consisted of PUD patients without CKD. A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals, to determine whether the occurrence of H. pyloriinfection in CKD or ESRDpatients with PUD differed from that of PUD patients without CKD. RESULTS: Among the CKD patients, 261 patients had H. pylori-positive and 185 H. pylori-negative peptic ulcers. Among the ESRDpatients, 81 had H. pylori-positive and 63 H. pylori-negative peptic ulcers. Among the non-CKD control patients, 1658 patients had H. pylori-positive and 702 H. pylori-negative peptic ulcers. Our results revealed a lower H. pyloriinfection rate in CKD (OR = 0.64, p < 0.001) and ESRD (OR = 0.54, p = 0.001) patients with PUD than in PUD patients without CKD. CONCLUSION: The H. pyloriinfection rate is lower in PUD patients with CKD and ESRD than in those without CKD.
Authors: Jae Hyun Seo; Su Jin Hong; Jie-Hyun Kim; Byung-Wook Kim; Sam Ryong Jee; Woo Chul Chung; Ki-Nam Shim; Gwang Ho Baik; Sung Soo Kim; Sang Gyun Kim; Jin Il Kim Journal: Gut Liver Date: 2016-09-15 Impact factor: 4.519