| Literature DB >> 24907018 |
Abstract
In the last 2 decades an increasing number of patients reported with extramedullary involvement among relapsed acute promyelocytic leukemia (APL) patients. Several investigators related this phenomenon to the relatively new treatment of all-trans-retinoic-acid (ATRA). In this review article we will examine what has been reported in the medical literature on extramedullary disease in APL: the common sites to be involved, the clinical risk factors to its development, the role of ATRA and arsenic tri-oxide and the recommended treatment.Entities:
Keywords: APL; CNS relapse; acute promyelocytic leukemia; extramedullary disease
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Year: 2014 PMID： 24907018 DOI： 10.1016/j.beha.2014.04.001
Source DB: PubMed Journal: Best Pract Res Clin Haematol ISSN： 1521-6926 Impact factor: 3.020