David J Mener1, Joshua Betz2, Kristine Yaffe3, Tamara B Harris4, Elizabeth P Helzner5, Suzanne Satterfield6, Denise K Houston7, Elsa S Strotmeyer8, Sheila R Pratt9, Eleanor M Simonsick10, Frank R Lin. 1. Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA. 2. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, USA. 3. Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, CA, USA Departments of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. 4. Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Baltimore, MD, USA. 5. Department of Epidemiology and Biostatistics, State University of New York, Downstate Medical Center, Brooklyn, NY, USA. 6. Department of Preventive Medicine, University of Tennessee, Memphis, TN, USA. 7. Wake Forest School of Medicine, Sticht Center on Aging, Winston Salem, NC, USA. 8. Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania. 9. Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare Center, Pittsburgh, PA, USA Department of Communication Science & Disorders, University of Pittsburgh, Pittsburgh, PA, USA. 10. Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Abstract
BACKGROUND: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. METHODS: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. RESULTS: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P = .013) and 8.0 kHz (β = -3.05 kHz, P = .006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P = .021). CONCLUSION: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.
BACKGROUND: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. METHODS: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. RESULTS: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P = .013) and 8.0 kHz (β = -3.05 kHz, P = .006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P = .021). CONCLUSION: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.
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