| Literature DB >> 24906744 |
Monica Mattioli-Belmonte1, Stefania Cometa2, Concetta Ferretti3, Roberta Iatta4, Adriana Trapani5, Edmondo Ceci6, Mirella Falconi7, Elvira De Giglio8.
Abstract
A novel ciprofloxacin loaded chitosan nanoparticle-based coating onto titanium substrates has been developed and characterized to obtain an orthopaedic implant surface able to in situ release the antibiotic for the prevention of post-operative infections. Ciprofloxacin loaded chitosan nanoparticles were obtained using the combination of sulfobutyl ether-beta-cyclodextrin and gamma-cyclodextrin. The resulting nanoparticulate system was characterized by TEM, HPLC and XPS. Particle size was in the range 426-552 nm and zeta potential values were around +30 mV. This antibacterial coating was able to in vitro inhibit two nosocomial Staphylococcus aureus strains growth, with a reduction of about 20 times compared to controls. No impairment in MG63 osteoblast-like cells viability, adhesion and gene expression were detected at 48 h, 7 and 14 days of culture. Overall, the investigated coating represents a promising candidate for the development of a new antibiotic carrier for titanium implants.Entities:
Keywords: Chitosan nanoparticles; Ciprofloxacin; Cyclodextrins; Cytocompatibility; Gene expression; Orthopaedic infections
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Year: 2014 PMID： 24906744 DOI： 10.1016/j.carbpol.2014.03.097
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381