PURPOSE: KRAS oncogene testing is recommended in all patients with metastatic colorectal cancer due to its impact on treatment selection, but we do not know if KRAS genotype affects extent or pattern of metastases. We investigated whether the initial radiographic distribution of disease varies by KRAS genotype in stage IV colorectal cancer. MATERIALS AND METHODS: This retrospective study of 65 patients with stage IV colorectal cancer was derived from an institutional clinical trials database. Inclusion criteria required KRAS testing and pretreatment CT studies to be available. Disease burden was characterized by two radiologists. RESULTS: Univariate analysis showed that there was no significant difference in the initial distribution of disease between KRAS mutant and wild type tumors (P > 0.05). Exploratory analyses showed that patients with poorly differentiated histology had a statistically significant increase in hepatic metastases in the presence of KRAS mutations vs. KRAS wild type genotype (median 5.0 vs. 0.5, P = 0.02). CONCLUSIONS: No overall difference was found in the initial radiographic distribution of disease between KRAS mutant and wild type colorectal cancers. Patients with both poorly differentiated histology and KRAS mutations had more liver metastases in subgroup analyses.
PURPOSE:KRAS oncogene testing is recommended in all patients with metastatic colorectal cancer due to its impact on treatment selection, but we do not know if KRAS genotype affects extent or pattern of metastases. We investigated whether the initial radiographic distribution of disease varies by KRAS genotype in stage IV colorectal cancer. MATERIALS AND METHODS: This retrospective study of 65 patients with stage IV colorectal cancer was derived from an institutional clinical trials database. Inclusion criteria required KRAS testing and pretreatment CT studies to be available. Disease burden was characterized by two radiologists. RESULTS: Univariate analysis showed that there was no significant difference in the initial distribution of disease between KRAS mutant and wild type tumors (P > 0.05). Exploratory analyses showed that patients with poorly differentiated histology had a statistically significant increase in hepatic metastases in the presence of KRAS mutations vs. KRAS wild type genotype (median 5.0 vs. 0.5, P = 0.02). CONCLUSIONS: No overall difference was found in the initial radiographic distribution of disease between KRAS mutant and wild type colorectal cancers. Patients with both poorly differentiated histology and KRAS mutations had more liver metastases in subgroup analyses.
Authors: Olivier Gevaert; Jiajing Xu; Chuong D Hoang; Ann N Leung; Yue Xu; Andrew Quon; Daniel L Rubin; Sandy Napel; Sylvia K Plevritis Journal: Radiology Date: 2012-06-21 Impact factor: 11.105
Authors: Jean-Yves Douillard; Kelly S Oliner; Salvatore Siena; Josep Tabernero; Ronald Burkes; Mario Barugel; Yves Humblet; Gyorgy Bodoky; David Cunningham; Jacek Jassem; Fernando Rivera; Ilona Kocákova; Paul Ruff; Maria Błasińska-Morawiec; Martin Šmakal; Jean Luc Canon; Mark Rother; Richard Williams; Alan Rong; Jeffrey Wiezorek; Roger Sidhu; Scott D Patterson Journal: N Engl J Med Date: 2013-09-12 Impact factor: 91.245
Authors: L Weiss; E Grundmann; J Torhorst; F Hartveit; I Moberg; M Eder; C M Fenoglio-Preiser; J Napier; C H Horne; M J Lopez Journal: J Pathol Date: 1986-11 Impact factor: 7.996
Authors: B Vogelstein; E R Fearon; S R Hamilton; S E Kern; A C Preisinger; M Leppert; Y Nakamura; R White; A M Smits; J L Bos Journal: N Engl J Med Date: 1988-09-01 Impact factor: 91.245
Authors: Christophe Rosty; Joanne P Young; Michael D Walsh; Mark Clendenning; Rhiannon J Walters; Sally Pearson; Erika Pavluk; Belinda Nagler; David Pakenas; Jeremy R Jass; Mark A Jenkins; Aung Ko Win; Melissa C Southey; Susan Parry; John L Hopper; Graham G Giles; Elizabeth Williamson; Dallas R English; Daniel D Buchanan Journal: Mod Pathol Date: 2013-01-25 Impact factor: 7.842
Authors: Andra Tilgase; Evija Olmane; Jurijs Nazarovs; Linda Brokāne; Romualds Erdmanis; Agnija Rasa; Pēteris Alberts Journal: Case Rep Gastroenterol Date: 2018-08-23