Wojciech Sobiczewski1, Marcin Wirtwein2, Marcin Gruchała1, Ivan Kocić3. 1. I Department of Cardiology, Medical University of Gdansk, Gdańsk, Poland. 2. Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland. Electronic address: marwirt@interia.pl. 3. Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland.
Abstract
BACKGROUND: The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality. METHODS: Subjects with established coronary heart disease (CHD) (n = 1345, mean age 63.2 ± 9.2 years) were included. RESULTS: Non-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00-4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02-1.47) and non-nighttime antihypertensive drug administration (HR 1.13, 95% CI 1.01-1.45) were predictors of all-cause mortality. CONCLUSIONS: The non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime.
BACKGROUND: The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality. METHODS: Subjects with established coronary heart disease (CHD) (n = 1345, mean age 63.2 ± 9.2 years) were included. RESULTS: Non-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00-4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02-1.47) and non-nighttime antihypertensive drug administration (HR 1.13, 95% CI 1.01-1.45) were predictors of all-cause mortality. CONCLUSIONS: The non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime.
Authors: Ramón C Hermida; Michael H Smolensky; Horia Balan; Richard J Castriotta; Juan J Crespo; Yaron Dagan; Sherine El-Toukhy; José R Fernández; Garret A FitzGerald; Akio Fujimura; Yong-Jian Geng; Ramón G Hermida-Ayala; Antonio P Machado; Luiz Menna-Barreto; Artemio Mojón; Alfonso Otero; R Daniel Rudic; Eva Schernhammer; Carsten Skarke; Tomoko Y Steen; Martin E Young; Xiaoyun Zhao Journal: Chronobiol Int Date: 2020-12-20 Impact factor: 3.749