| Literature DB >> 24905419 |
Huy V Nguyen1, Antoine Sallustrau, Jan Balzarini, Matthew R Bedford, John C Eden, Niki Georgousi, Nikolas J Hodges, Jonathan Kedge, Youcef Mehellou, Chris Tselepis, James H R Tucker.
Abstract
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.Entities:
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Year: 2014 PMID： 24905419 DOI： 10.1021/jm500246h
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446