Dilip Dodda1, Ruchi Chhajed2, Jitendriya Mishra3. 1. University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India; Department of Pharmacology, Vaagdevi College of Pharmacy, Warangal, India. Electronic address: dilipd4u@gmail.com. 2. Department of Pharmacology, NMT Gujarati College of Pharmacy, Indore, India. 3. Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Ganjam, Odisha, India; University Institute of Pharmaceutical Sciences, UGC Center of Advanced Studies, Panjab University, Chandigarh, India.
Abstract
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by most common symptoms such as rectal bleeding. Lack of specific, curative treatments tempted us to evaluate the therapeutic efficacy of quercetin against acetic acid induced IBD like symptoms. METHODS: Animals were randomly divided into five groups (n = 6): naive, control, sulphasalazine and quercetin, and were pretreated for three days. Colitis was induced by intra-rectal administration of 3% acetic acid. RESULTS: Pretreatment with sulphasalazine or quercetin significantly attenuated the biochemical and morphological alterations in the colon induced by acetic acid in rats. CONCLUSIONS: The findings of the study suggest the possible role of quercetin as therapeutics in IBD.
BACKGROUND:Inflammatory bowel disease (IBD) is characterized by most common symptoms such as rectal bleeding. Lack of specific, curative treatments tempted us to evaluate the therapeutic efficacy of quercetin against acetic acid induced IBD like symptoms. METHODS: Animals were randomly divided into five groups (n = 6): naive, control, sulphasalazine and quercetin, and were pretreated for three days. Colitis was induced by intra-rectal administration of 3% acetic acid. RESULTS: Pretreatment with sulphasalazine or quercetin significantly attenuated the biochemical and morphological alterations in the colon induced by acetic acid in rats. CONCLUSIONS: The findings of the study suggest the possible role of quercetin as therapeutics in IBD.
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