OBJECTIVE: Numerous studies examining the relationship between human epidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value. METHODS: Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival. RESULTS: Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77-1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50-1.29; HR=0.90, 95% CI: 0.43-1.37, respectively). CONCLUSIONS: Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival.
OBJECTIVE: Numerous studies examining the relationship between humanepidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value. METHODS: Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival. RESULTS: Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77-1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50-1.29; HR=0.90, 95% CI: 0.43-1.37, respectively). CONCLUSIONS: Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival.
Entities:
Keywords:
Colorectal cancer (CRC); Human epidermal growth factor receptor 2 (HER-2); Meta-analysis; Survival
Authors: Lena-Christin Conradi; Hanna Styczen; Thilo Sprenger; Hendrik A Wolff; Claus Rödel; Manuel Nietert; Kia Homayounfar; Jochen Gaedcke; Julia Kitz; Recca Talaulicar; Heinz Becker; Michael Ghadimi; Peter Middel; Tim Beissbarth; Josef Rüschoff; Torsten Liersch Journal: Am J Surg Pathol Date: 2013-04 Impact factor: 6.394
Authors: Umut Disel; Alexis Germain; Bahar Yilmazel; Huseyin Abali; Filiz Aka Bolat; Roman Yelensky; Julia A Elvin; Doron Lipson; Juliann Chmielecki; Kai Wang; Philip J Stephens; Jeffrey S Ross; Vincent A Miller; Siraj M Ali; Thomas J George Journal: Oncoscience Date: 2015-07-01