Literature DB >> 24903896

Validation of a non-linear model of health.

Stefan Topolski1, Joachim Sturmberg.   

Abstract

PURPOSE: The purpose of this study was to evaluate the veracity of a theoretically derived model of health that describes a non-linear trajectory of health from birth to death with available population data sets.
METHODS: The distribution of mortality by age is directly related to health at that age, thus health approximates 1/mortality. The inverse of available all-cause mortality data from various time periods and populations was used as proxy data to compare with the theoretically derived non-linear health model predictions, using both qualitative approaches and quantitative one-sample Kolmogorov-Smirnov analysis with Monte Carlo simulation.
RESULTS: The mortality data's inverse resembles a log-normal distribution as predicted by the proposed health model. The curves have identical slopes from birth and follow a logarithmic decline from peak health in young adulthood. A majority of the sampled populations had a good to excellent quantitative fit to a log-normal distribution, supporting the underlying model assumptions. Post hoc manipulation showed the model predictions to be stable.
CONCLUSIONS: This is a first theory of health to be validated by proxy data, namely the inverse of all-cause mortality. This non-linear model, derived from the notion of the interaction of physical, environmental, mental, emotional, social and sense-making domains of health, gives physicians a more rigorous basis to direct health care services and resources away from disease-focused elder care towards broad-based biopsychosocial interventions earlier in life.
© 2014 John Wiley & Sons, Ltd.

Keywords:  chaos; complex systems; complexity; computer modelling; entropy; epidemiology; health; illness; information theory; mortality; philosophy of medicine; probability; theory

Mesh:

Year:  2014        PMID: 24903896     DOI: 10.1111/jep.12162

Source DB:  PubMed          Journal:  J Eval Clin Pract        ISSN: 1356-1294            Impact factor:   2.431


  1 in total

1.  The trajectory of life. Decreasing physiological network complexity through changing fractal patterns.

Authors:  Joachim P Sturmberg; Jeanette M Bennett; Martin Picard; Andrew J E Seely
Journal:  Front Physiol       Date:  2015-06-02       Impact factor: 4.566

  1 in total

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