Seung Ook Hwang 1 , Sang-Woo Lee 2 , Jin Koo Kang 1 , Hyang Hee Choi 1 , Wan Wook Kim 1 , Ho Yong Park 1 , Jin Hyang Jung 3 Show Affiliations »
Abstract
OBJECTIVE: This study evaluates the relationship between visually identifiable (18)F-fluorodeoxyglucose (FDG) uptake in primary papillary thyroid microcarcinoma (PTMC) and tumor aggressiveness. STUDY DESIGN: Historical cohort study. SETTING: Tertiary care center. METHODS: Clinicopathological factors and PET/CT findings of 219 PTMC surgical patients who underwent preoperative (18)F-FDG positron emission tomography/computed tomography (PET/CT) were retrospectively reviewed. RESULTS: (18)F-FDG uptake was observed in the tumors of 124 (56.6%) patients. Tumor size (odds ratio [OR] = 1.774; 95% confidence interval [CI], 1.416-2.223; P < .0001) and Hashimoto thyroiditis (OR = 2.815; CI, 1.237-6.404; P = .014) independently predicted (18)F-FDG uptake. Tumor size (OR = 1.495; CI, 1.217-1.835; P < .0001) and BRAF(V600E) mutation (OR = 3.320; CI, 1.056-10.432; P = .040) independently predicted extrathyroidal invasion. Multiplicity (OR = 2.375; CI, 1.278-4.415; P = .006) independently predicted central lymph node metastasis. CONCLUSION: (18)F-FDG uptake in PTMC depends on tumor size and Hashimoto thyroiditis. Therefore, preoperative PET/CT for PTMC may not help in evaluating tumor aggressiveness. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.
OBJECTIVE: This study evaluates the relationship between visually identifiable (18)F-fluorodeoxyglucose (FDG ) uptake in primary papillary thyroid microcarcinoma (PTMC) and tumor aggressiveness . STUDY DESIGN: Historical cohort study. SETTING: Tertiary care center. METHODS: Clinicopathological factors and PET/CT findings of 219 PTMC surgical patients who underwent preoperative (18)F-FDG positron emission tomography/computed tomography (PET/CT) were retrospectively reviewed. RESULTS: (18)F-FDG uptake was observed in the tumors of 124 (56.6%) patients . Tumor size (odds ratio [OR] = 1.774; 95% confidence interval [CI], 1.416-2.223; P < .0001) and Hashimoto thyroiditis (OR = 2.815; CI, 1.237-6.404; P = .014) independently predicted (18)F-FDG uptake. Tumor size (OR = 1.495; CI, 1.217-1.835; P < .0001) and BRAF( V600E ) mutation (OR = 3.320; CI, 1.056-10.432; P = .040) independently predicted extrathyroidal invasion. Multiplicity (OR = 2.375; CI, 1.278-4.415; P = .006) independently predicted central lymph node metastasis. CONCLUSION: (18)F-FDG uptake in PTMC depends on tumor size and Hashimoto thyroiditis . Therefore, preoperative PET/CT for PTMC may not help in evaluating tumor aggressiveness . © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.
Entities: Chemical
Disease
Gene
Mutation
Species
Keywords:
18F-fluorodeoxyglucose uptake; extrathyroidal invasion; lymph node metastasis; papillary thyroid microcarcinoma; positron emission tomography/computed tomography
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Year: 2014
PMID： 24903453 DOI： 10.1177/0194599814537224
Source DB: PubMed Journal: Otolaryngol Head Neck Surg ISSN： 0194-5998 Impact factor: 3.497