Literature DB >> 24903342

Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

H M-F Viart1, T S Larsen, C Tassone, T L Andresen, M H Clausen.   

Abstract

A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.

Entities:  

Mesh:

Substances:

Year:  2014        PMID: 24903342     DOI: 10.1039/c4cc00863d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  N-Propargylamines: versatile building blocks in the construction of thiazole cores.

Authors:  S Arshadi; E Vessally; L Edjlali; R Hosseinzadeh-Khanmiri; E Ghorbani-Kalhor
Journal:  Beilstein J Org Chem       Date:  2017-03-30       Impact factor: 2.883

2.  Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.

Authors:  Elena Sanna; Margarida Rodrigues; Steven G Fagan; Timothy S Chisholm; Klara Kulenkampff; David Klenerman; Maria Grazia Spillantini; Franklin I Aigbirhio; Christopher A Hunter
Journal:  Chem Sci       Date:  2021-06-07       Impact factor: 9.825

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.