OBJECTIVE: To present the long-term outcome of multidrug-resistant tuberculosis (MDR TB) patients. METHODS: An observational study of 291 MDR TB cases that were diagnosed from 1990 to 2011 at the Fukujuji Hospital in Japan. RESULTS: The frequency of relapse after cure was 3/168 (1.8%) during a mean follow-up of 4.4 years. Among 16 failure cases, eight patients were negative in later years. One case among the nine lost-to-follow-up patients with culture conversion returned 1.5 years later with positive culture. CONCLUSIONS: Chronic-positive patients remain positive for years and require observation. Lost to follow-up cases may relapse.
OBJECTIVE: To present the long-term outcome of multidrug-resistant tuberculosis (MDR TB) patients. METHODS: An observational study of 291 MDR TB cases that were diagnosed from 1990 to 2011 at the Fukujuji Hospital in Japan. RESULTS: The frequency of relapse after cure was 3/168 (1.8%) during a mean follow-up of 4.4 years. Among 16 failure cases, eight patients were negative in later years. One case among the nine lost-to-follow-up patients with culture conversion returned 1.5 years later with positive culture. CONCLUSIONS: Chronic-positive patients remain positive for years and require observation. Lost to follow-up cases may relapse.
Authors: J M Mangan; T E Tupasi; A M C G Garfin; V Lofranco; R Orillaza-Chi; R Basilio; L C Naval; G I Balane; E S Joson; D Burt; W-J Lew; M Mantala; S Pancho; J N Sarol; A Golubkov; E V Kurbatova Journal: Int J Tuberc Lung Dis Date: 2016-09 Impact factor: 2.373