| Literature DB >> 24900944 |
Chandan Prasad1, Victorine Imrhan1, Francesco Marotta2, Shanil Juma1, Parakat Vijayagopal1.
Abstract
Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.Entities:
Keywords: Aging; glycation; oxidative stress; reactive nitrogen species; reactive oxygen species
Year: 2014 PMID: 24900944 PMCID: PMC4037313 DOI: 10.14336/AD.2014.0500212
Source DB: PubMed Journal: Aging Dis ISSN: 2152-5250 Impact factor: 6.745