Literature DB >> 24900873

Cryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4.

Michael F Cuccarese1, Yanping Wang1, Penny J Beuning1, George A O'Doherty1.   

Abstract

The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor suppressor PDCD4. Cytotoxicities in the 3 to 30 μM range were found. Both the cytotoxicity and PDCD4 stabilizing ability were tolerant of large stereochemical changes to the molecule. Co-dosing studies with cryptocaryols A and B and several known cancer drugs showed no measuable enhancement in cancer drug cytotoxicity.

Entities:  

Keywords:  PDCD4; PDCD4 stabilizer; cryptocaryol SAR; cryptocaryols

Year:  2014        PMID： 24900873      PMCID： PMC4029205          DOI： 10.1021/ml4005039

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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