Literature DB >> 24900858

Systems biology approach to developing "systems therapeutics".

Greg Maguire1.   

Abstract

The standard drug development model uses reductionist approaches to discover small molecules targeting one pathway. Although systems biology analyzes multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. Similar to that in physics where a departure from the old reductionist "Copenhagen View" of quantum physics to a new and predictive systems based, collective model has emerged yielding new breakthroughs such as the LASER, a new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called "systems therapeutics."

Year:  2014        PMID: 24900858      PMCID: PMC4027758          DOI: 10.1021/ml5000614

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN: 1948-5875            Impact factor:   4.345


  8 in total

1.  Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations.

Authors:  D NOBLE
Journal:  Nature       Date:  1960-11-05       Impact factor: 49.962

2.  A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-08       Impact factor: 5.182

Review 3.  Neo-Darwinism, the modern synthesis and selfish genes: are they of use in physiology?

Authors:  Denis Noble
Journal:  J Physiol       Date:  2010-12-06       Impact factor: 5.182

Review 4.  Using a systems-based approach to overcome reductionist strategies in the development of diagnostics.

Authors:  Greg Maguire
Journal:  Expert Rev Mol Diagn       Date:  2013-10-21       Impact factor: 5.225

5.  A theory of biological relativity: no privileged level of causation.

Authors:  Denis Noble
Journal:  Interface Focus       Date:  2011-11-09       Impact factor: 3.906

6.  Increased l1 retrotransposition in the neuronal genome in schizophrenia.

Authors:  Miki Bundo; Manabu Toyoshima; Yohei Okada; Wado Akamatsu; Junko Ueda; Taeko Nemoto-Miyauchi; Fumiko Sunaga; Michihiro Toritsuka; Daisuke Ikawa; Akiyoshi Kakita; Motoichiro Kato; Kiyoto Kasai; Toshifumi Kishimoto; Hiroyuki Nawa; Hideyuki Okano; Takeo Yoshikawa; Tadafumi Kato; Kazuya Iwamoto
Journal:  Neuron       Date:  2014-01-02       Impact factor: 17.173

7.  Aging research 2011: exploring the pet dog paradigm.

Authors:  David J Waters
Journal:  ILAR J       Date:  2011

8.  Stem cell therapy without the cells.

Authors:  Greg Maguire
Journal:  Commun Integr Biol       Date:  2013-09-27
  8 in total
  10 in total

1.  Maturing from embryonic to adult policy on stem cell therapeutics.

Authors:  Greg Maguire
Journal:  ACS Med Chem Lett       Date:  2014-10-08       Impact factor: 4.345

Review 2.  Systems biology approach to developing S(2)RM-based "systems therapeutics" and naturally induced pluripotent stem cells.

Authors:  Greg Maguire; Peter Friedman
Journal:  World J Stem Cells       Date:  2015-05-26       Impact factor: 5.326

3.  Therapeutics from Adult Stem Cells and the Hype Curve.

Authors:  Greg Maguire
Journal:  ACS Med Chem Lett       Date:  2016-04-25       Impact factor: 4.345

4.  The safety of a therapeutic product composed of a combination of stem cell released molecules from adipose mesenchymal stem cells and fibroblasts.

Authors:  Greg Maguire; Peter Friedman
Journal:  Future Sci OA       Date:  2020-05-29

5.  Transplanted stem cells survive a long time: do they make you sick?

Authors:  Greg Maguire
Journal:  J R Soc Med       Date:  2019-09-17       Impact factor: 18.000

Review 6.  Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules.

Authors:  Greg Maguire
Journal:  World J Stem Cells       Date:  2017-11-26       Impact factor: 5.326

7.  Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes.

Authors:  Greg Maguire; Christy Eubanks; George Ayoub
Journal:  Neuronal Signal       Date:  2022-02-16

8.  Using a "systems therapeutic for physiological renormalization" approach to vaccine development. Covid-19 as an example.

Authors:  Greg Maguire
Journal:  Hum Vaccin Immunother       Date:  2022-03-03       Impact factor: 4.526

9.  Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy.

Authors:  Greg Maguire; Lee Paler; Linda Green; Rosa Mella; Maria Valcarcel; Patricia Villace
Journal:  Physiol Rep       Date:  2019-05

10.  Multi-dimensional computational pipeline for large-scale deep screening of compound effect assessment: an in silico case study on ageing-related compounds.

Authors:  Vipul Gupta; Alina Crudu; Yukiko Matsuoka; Samik Ghosh; Roger Rozot; Xavier Marat; Sibylle Jäger; Hiroaki Kitano; Lionel Breton
Journal:  NPJ Syst Biol Appl       Date:  2019-11-26
  10 in total

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