Literature DB >> 24900790

Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone.

Jérémy Thireau1, Justine Marteaux1, Philippe Delagrange2, Francois Lefoulon3, Laurence Dufourny4, Gérald Guillaumet1, Franck Suzenet1.   

Abstract

An original design and synthesis of fluorescent ligands for melatonin receptor studies is presented and consists in the fusion of the endogenous ligand with the fluorescent BODIPY core. Probes I-IV show high affinities for MT1 and MT2 melatonin receptors and exhibit fluorescence properties compatible with cell observation.

Entities:  

Keywords:  BODIPY; GPCRs; fluorescence; melatonin; molecular probes

Year:  2013        PMID： 24900790      PMCID： PMC4027590          DOI： 10.1021/ml4004155

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  29 in total

1.  Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.

Authors:  Matthieu Jeanty; Franck Suzenet; Philippe Delagrange; Olivier Nosjean; Jean A Boutin; Daniel H Caignard; Gérald Guillaumet
Journal:  Bioorg Med Chem Lett       Date:  2011-02-26       Impact factor: 2.823

Review 2.  Ligands for fluorescence correlation spectroscopy on g protein-coupled receptors.

Authors:  D Jakobs; T Sorkalla; H Häberlein
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

Review 3.  Therapeutic perspectives for melatonin agonists and antagonists.

Authors:  P Delagrange; J Atkinson; J A Boutin; L Casteilla; D Lesieur; R Misslin; S Pellissier; L Pénicaud; P Renard
Journal:  J Neuroendocrinol       Date:  2003-04       Impact factor: 3.627

4.  Development of an indole-based boron-dipyrromethene fluorescent probe for benzenethiols.

Authors:  Chunchang Zhao; Yu Zhou; Qiuning Lin; Linyong Zhu; Peng Feng; Yulin Zhang; Jian Cao
Journal:  J Phys Chem B       Date:  2010-12-17       Impact factor: 2.991

Review 5.  Melatonin receptor agonists: new options for insomnia and depression treatment.

Authors:  Gilberto Spadoni; Annalida Bedini; Silvia Rivara; Marco Mor
Journal:  CNS Neurosci Ther       Date:  2011-12       Impact factor: 5.243

6.  Vicarious nucleophilic substitution of α-hydrogen of BODIPY and its extension to direct ethenylation.

Authors:  Volker Leen; Mark Van der Auweraer; Noël Boens; Wim Dehaen
Journal:  Org Lett       Date:  2011-02-18       Impact factor: 6.005

7.  Synthesis of 4- and 6-azaindoles via the Fischer reaction.

Authors:  Matthieu Jeanty; Jérôme Blu; Franck Suzenet; Gérald Guillaumet
Journal:  Org Lett       Date:  2009-11-19       Impact factor: 6.005

8.  First synthesis of free cholesterol-BODIPY conjugates.

Authors:  Zaiguo Li; Evan Mintzer; Robert Bittman
Journal:  J Org Chem       Date:  2006-02-17       Impact factor: 4.354

9.  Functionalization of boron dipyrrin (BODIPY) dyes through iridium and rhodium catalysis: a complementary approach to alpha- and beta-substituted BODIPYs.

Authors:  Jinping Chen; Masatoshi Mizumura; Hiroshi Shinokubo; Atsuhiro Osuka
Journal:  Chemistry       Date:  2009-06-08       Impact factor: 5.236

Review 10.  Agomelatine, the first melatonergic antidepressant: discovery, characterization and development.

Authors:  Christian de Bodinat; Béatrice Guardiola-Lemaitre; Elisabeth Mocaër; Pierre Renard; Carmen Muñoz; Mark J Millan
Journal:  Nat Rev Drug Discov       Date:  2010-06-25       Impact factor: 84.694
View more
  5 in total

Review 1.  Melatonin receptors: molecular pharmacology and signalling in the context of system bias.

Authors:  Erika Cecon; Atsuro Oishi; Ralf Jockers
Journal:  Br J Pharmacol       Date:  2017-08-17       Impact factor: 8.739

2.  Design and validation of the first cell-impermeant melatonin receptor agonist.

Authors:  Florence Gbahou; Erika Cecon; Guillaume Viault; Romain Gerbier; Frederic Jean-Alphonse; Angeliki Karamitri; Gérald Guillaumet; Philippe Delagrange; Robert M Friedlander; Jean-Pierre Vilardaga; Franck Suzenet; Ralf Jockers
Journal:  Br J Pharmacol       Date:  2017-06-11       Impact factor: 8.739

3.  Luminogenic HiBiT Peptide-Based NanoBRET Ligand Binding Assays for Melatonin Receptors.

Authors:  Florence Gbahou; Sergiy Levin; Irina G Tikhonova; Gloria Somalo Barranco; Charlotte Izabelle; Rachel Friedman Ohana; Ralf Jockers
Journal:  ACS Pharmacol Transl Sci       Date:  2022-07-18

4.  Synthesis and characterization of new fluorescent boro-β-carboline dyes.

Authors:  Dénes Szepesi Kovács; Imre Hajdu; Gergely Mészáros; Lucia Wittner; Domokos Meszéna; Estilla Zsófia Tóth; Zita Hegedűs; Ivan Ranđelović; József Tóvári; Tímea Szabó; Bence Szilágyi; Mátyás Milen; György Miklós Keserű; Péter Ábrányi-Balogh
Journal:  RSC Adv       Date:  2021-04-01       Impact factor: 3.361

Review 5.  Melatonin Receptors: A Key Mediator in Animal Reproduction.

Authors:  Yuan Gao; Shuqin Zhao; Yong Zhang; Quanwei Zhang
Journal:  Vet Sci       Date:  2022-06-22
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.