Literature DB >> 24900715

Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections.

Angus M MacLeod1, Dale R Mitchell1, Nicholas J Palmer1, Hervé Van de Poël1, Katja Conrath2, Martin Andrews2, Pieter Leyssen3, Johan Neyts3.   

Abstract

Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIIIβ. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.

Entities:  

Keywords:  HCV; PI4KIIIβ; antiviral; enterovirus; inhibitor

Year:  2013        PMID： 24900715      PMCID： PMC4030314          DOI： 10.1021/ml400095m

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  18 in total

1.  Safety and efficacy evaluation of pleconaril for treatment of the common cold.

Authors:  Russell Fleischer; Katherine Laessig
Journal:  Clin Infect Dis       Date:  2003-12-15       Impact factor: 9.079

2.  Intranasal pirodavir (R77,975) treatment of rhinovirus colds.

Authors:  F G Hayden; G J Hipskind; D H Woerner; G F Eisen; M Janssens; P A Janssen; K Andries
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

3.  Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.

Authors:  M J Lamarche; J Borawski; A Bose; C Capacci-Daniel; R Colvin; M Dennehy; J Ding; M Dobler; J Drumm; L A Gaither; J Gao; X Jiang; K Lin; U McKeever; X Puyang; P Raman; S Thohan; R Tommasi; K Wagner; X Xiong; T Zabawa; S Zhu; B Wiedmann
Journal:  Antimicrob Agents Chemother       Date:  2012-07-23       Impact factor: 5.191

4.  Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study.

Authors:  Jonathan M Corne; Clare Marshall; Sandra Smith; Jacquie Schreiber; Gwendolyn Sanderson; Stephen T Holgate; Sebastian L Johnston
Journal:  Lancet       Date:  2002-03-09       Impact factor: 79.321

Review 5.  Selective inhibitors of picornavirus replication.

Authors:  Armando M De Palma; Inge Vliegen; Erik De Clercq; Johan Neyts
Journal:  Med Res Rev       Date:  2008-11       Impact factor: 12.944

6.  Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

Authors:  Jason Borawski; Philip Troke; Xiaoling Puyang; Veronica Gibaja; Shanchaun Zhao; Craig Mickanin; Juliet Leighton-Davies; Christopher J Wilson; Vic Myer; Ivan Cornellataracido; Jeremy Baryza; John Tallarico; Gerard Joberty; Marcus Bantscheff; Markus Schirle; Tewis Bouwmeester; Joanna E Mathy; Kai Lin; Teresa Compton; Mark Labow; Brigitte Wiedmann; L Alex Gaither
Journal:  J Virol       Date:  2009-07-15       Impact factor: 5.103

7.  Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations.

Authors:  Alberto Papi; Cinzia Maria Bellettato; Fausto Braccioni; Micaela Romagnoli; Paolo Casolari; Gaetano Caramori; Leonardo M Fabbri; Sebastian L Johnston
Journal:  Am J Respir Crit Care Med       Date:  2006-02-16       Impact factor: 21.405

8.  Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.

Authors:  Frederick G Hayden; Ronald B Turner; Jack M Gwaltney; Kathy Chi-Burris; Merril Gersten; Poe Hsyu; Amy K Patick; George J Smith; Leora S Zalman
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

9.  Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity.

Authors:  Minetaro Arita; Hirotatsu Kojima; Tetsuo Nagano; Takayoshi Okabe; Takaji Wakita; Hiroyuki Shimizu
Journal:  J Virol       Date:  2010-12-22       Impact factor: 6.549

10.  Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials.

Authors:  Frederick G Hayden; Darrell T Herrington; Teresa L Coats; Kenneth Kim; Ellen C Cooper; Stephen A Villano; Siyu Liu; Spencer Hudson; Daniel C Pevear; Marc Collett; Mark McKinlay
Journal:  Clin Infect Dis       Date:  2003-06-06       Impact factor: 9.079
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  13 in total

Review 1.  Lipid Tales of Viral Replication and Transmission.

Authors:  Nihal Altan-Bonnet
Journal:  Trends Cell Biol       Date:  2016-11-09       Impact factor: 20.808

2.  A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

Authors:  Hilde M van der Schaar; Pieter Leyssen; Hendrik J Thibaut; Armando de Palma; Lonneke van der Linden; Kjerstin H W Lanke; Céline Lacroix; Erik Verbeken; Katja Conrath; Angus M Macleod; Dale R Mitchell; Nicholas J Palmer; Hervé van de Poël; Martin Andrews; Johan Neyts; Frank J M van Kuppeveld
Journal:  Antimicrob Agents Chemother       Date:  2013-07-29       Impact factor: 5.191

3.  Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein.

Authors:  Cristina M Dorobantu; Lucian Albulescu; Heyrhyoung Lyoo; Mirjam van Kampen; Raffaele De Francesco; Volker Lohmann; Christian Harak; Hilde M van der Schaar; Jeroen R P M Strating; Alexander E Gorbalenya; Frank J M van Kuppeveld
Journal:  mSphere       Date:  2016-05-11       Impact factor: 4.389

4.  Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.

Authors:  Charlotte E Melia; Hilde M van der Schaar; Heyrhyoung Lyoo; Ronald W A L Limpens; Qian Feng; Maryam Wahedi; Gijs J Overheul; Ronald P van Rij; Eric J Snijder; Abraham J Koster; Montserrat Bárcena; Frank J M van Kuppeveld
Journal:  Cell Rep       Date:  2017-10-17       Impact factor: 9.423

5.  Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner.

Authors:  Lisa Bauer; Roberto Manganaro; Birgit Zonsics; Jeroen R P M Strating; Priscila El Kazzi; Moira Lorenzo Lopez; Rachel Ulferts; Clara van Hoey; Maria J Maté; Thierry Langer; Bruno Coutard; Andrea Brancale; Frank J M van Kuppeveld
Journal:  ACS Infect Dis       Date:  2019-07-31       Impact factor: 5.084

Review 6.  Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis.

Authors:  Andreas Schapowal; Gustav Dobos; Holger Cramer; Kian Chung Ong; Martin Adler; Andrea Zimmermann; Juliette Brandes-Schramm; Walter Lehmacher
Journal:  Heliyon       Date:  2019-11-26

7.  Selective Inhibition of Enterovirus A Species Members' Reproduction by Furano[2, 3-d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses.

Authors:  Liubov I Kozlovskaya; Anastasia D Golinets; Anastasia A Eletskaya; Alexey A Orlov; Vladimir A Palyulin; Sergey N Kochetkov; Liudmila A Alexandrova; Dmitry I Osolodkin
Journal:  ChemistrySelect       Date:  2018-02-27       Impact factor: 2.109

8.  Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Authors:  Jeroen R P M Strating; Lonneke van der Linden; Lucian Albulescu; Joëlle Bigay; Minetaro Arita; Leen Delang; Pieter Leyssen; Hilde M van der Schaar; Kjerstin H W Lanke; Hendrik Jan Thibaut; Rachel Ulferts; Guillaume Drin; Nina Schlinck; Richard W Wubbolts; Navdar Sever; Sarah A Head; Jun O Liu; Philip A Beachy; Maria A De Matteis; Matthew D Shair; Vesa M Olkkonen; Johan Neyts; Frank J M van Kuppeveld
Journal:  Cell Rep       Date:  2015-01-29       Impact factor: 9.423

9.  Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus.

Authors:  Cristina M Dorobantu; Lucian Albulescu; Christian Harak; Qian Feng; Mirjam van Kampen; Jeroen R P M Strating; Alexander E Gorbalenya; Volker Lohmann; Hilde M van der Schaar; Frank J M van Kuppeveld
Journal:  PLoS Pathog       Date:  2015-09-25       Impact factor: 6.823

Review 10.  The Autophagic Machinery in Enterovirus Infection.

Authors:  Jeffrey K F Lai; I-Ching Sam; Yoke Fun Chan
Journal:  Viruses       Date:  2016-01-27       Impact factor: 5.048
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