| Literature DB >> 24900644 |
Ji-Ae Park1, Jung Young Kim1, Yong Jin Lee1, Wonho Lee1, Sang Moo Lim1, Tae-Jeong Kim2, Jeongsoo Yoo3, Yongmin Chang3, Kyeong Min Kim1.
Abstract
The work describes the synthesis and in vivo application of [Gd(L)(H2O)]·xH2O, where L is a ((125)I/(127)I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, ((125)I/(127)I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = (125)I-RGD-DOTA) and natural (1b, L = (127)I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.Entities:
Keywords: RGD peptide; SPECT/MR; dual modality; small molecule; tumor targeting
Year: 2012 PMID： 24900644 PMCID： PMC4027545 DOI： 10.1021/ml3003499
Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345