Literature DB >> 24900559

Novel 2-aminobenzamides as potential orally active antithrombotic agents.

Amit Verma1, Rajani Giridhar1, Ashish Kanhed1, Anshuman Sinha1, Pratik Modh1, Mange R Yadav1.   

Abstract

In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.

Entities:  

Keywords:  2-aminobenzamide; antiplatelet; antithrombotic agents; ionic liquid; thromboembolic disorders

Year:  2012        PMID： 24900559      PMCID： PMC4027566          DOI： 10.1021/ml300217f

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  15 in total

Review 1.  The dynamics of thrombin formation.

Authors:  Kenneth G Mann; Saulius Butenas; Kathleen Brummel
Journal:  Arterioscler Thromb Vasc Biol       Date:  2003-01-01       Impact factor: 8.311

2.  Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes.

Authors:  Marc Nazaré; Hans Matter; David W Will; Michael Wagner; Matthias Urmann; Jörg Czech; Herman Schreuder; Armin Bauer; Kurt Ritter; Volkmar Wehner
Journal:  Angew Chem Int Ed Engl       Date:  2011-12-21       Impact factor: 15.336

3.  The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents.

Authors:  Pei-Wen Hsieh; Tsong-Long Hwang; Chin-Chung Wu; Shin-Zan Chiang; Chung-I Wu; Yang-Chang Wu
Journal:  Bioorg Med Chem Lett       Date:  2006-12-15       Impact factor: 2.823

4.  Bleeding time in laboratory animals. II - A comparison of different assay conditions in rats.

Authors:  E Dejana; A Callioni; A Quintana; G de Gaetano
Journal:  Thromb Res       Date:  1979       Impact factor: 3.944

5.  The N-aryl aminocarbonyl ortho-substituent effect in Cu-catalyzed aryl amination and its application in the synthesis of 5-substituted 11-oxo-dibenzodiazepines.

Authors:  Xiaoqiong Diao; Lanting Xu; Wei Zhu; Yongwen Jiang; Haoyang Wang; Yinlong Guo; Dawei Ma
Journal:  Org Lett       Date:  2011-11-16       Impact factor: 6.005

Review 6.  New anticoagulants for atrial fibrillation.

Authors:  Magdalena Sobieraj-Teague; Martin O'Donnell; John Eikelboom
Journal:  Semin Thromb Hemost       Date:  2009-09-08       Impact factor: 4.180

7.  Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors.

Authors:  Hiroyuki Koshio; Fukushi Hirayama; Tsukasa Ishihara; Ryouta Shiraki; Takeshi Shigenaga; Yuta Taniuchi; Kazuo Sato; Yumiko Moritani; Yoshiyuki Iwatsuki; Seiji Kaku; Naoko Katayama; Tomihisa Kawasaki; Yuzo Matsumoto; Shuichi Sakamoto; Shin-ichi Tsukamoto
Journal:  Bioorg Med Chem       Date:  2005-02-15       Impact factor: 3.641

8.  Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.

Authors:  Fukushi Hirayama; Hiroyuki Koshio; Tsukasa Ishihara; Shunichiro Hachiya; Keizo Sugasawa; Yuji Koga; Norio Seki; Ryouta Shiraki; Takeshi Shigenaga; Yoshiyuki Iwatsuki; Yumiko Moritani; Kenichi Mori; Takeshi Kadokura; Tomihisa Kawasaki; Yuzo Matsumoto; Shuichi Sakamoto; Shin-ichi Tsukamoto
Journal:  J Med Chem       Date:  2011-11-11       Impact factor: 7.446

9.  Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study.

Authors:  Roza Chaireti; Cecilia Jennersjö; Tomas L Lindahl
Journal:  Thromb Res       Date:  2009-02-20       Impact factor: 3.944

10.  Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol.

Authors:  G DiMinno; M J Silver
Journal:  J Pharmacol Exp Ther       Date:  1983-04       Impact factor: 4.030
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