Literature DB >> 24900548

Using medicinal chemistry to solve an old medical mystery.

William B Hinshaw1, Louis D Quin2.   

Abstract

The logic behind the traditional medicinal chemistry technique of designing a synthetic enzyme substrate to mimic a natural one is used to uncover the identity of the unknown cause of two legacy industrial diseases by comparing the reported symptoms to two side effects of a modern synthetic.

Year:  2012        PMID： 24900548      PMCID： PMC4027553          DOI： 10.1021/ml300430j

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  3 in total

1.  The effect of pyrophosphate infusion on the response of the thyroparathyroidectomized rat to parathyroid hormone and adenosine-3',5'-cyclic monophosphate.

Authors:  A Delong; J Feinblatt; H Rasmussen
Journal:  Calcif Tissue Res       Date:  1971

2.  Atypical femur fractures: 81 individual personal histories.

Authors:  Jennifer P Schneider; William B Hinshaw; Christina Su; Phyllis Solow
Journal:  J Clin Endocrinol Metab       Date:  2012-10-17       Impact factor: 5.958

3.  Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Authors:  James E Dunford; Aaron A Kwaasi; Michael J Rogers; Bobby L Barnett; Frank H Ebetino; R Graham G Russell; Udo Oppermann; Kathryn L Kavanagh
Journal:  J Med Chem       Date:  2008-03-08       Impact factor: 7.446
  3 in total

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