| Literature DB >> 24900324 |
Christopher F Thompson1, Amjad Ali1, Nazia Quraishi1, Zhijian Lu1, Milton L Hammond1, Peter J Sinclair1, Matt S Anderson1, Suzanne S Eveland1, Qiu Guo1, Sheryl A Hyland1, Denise P Milot1, Carl P Sparrow1, Samuel D Wright1.
Abstract
Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. Inhibition of cholesteryl ester transfer protein (CETP) has been shown to elevate HDL-C levels in human subjects. This letter describes the discovery of a novel and potent (<100 nM IC50 for the inhibition of CE transfer) CETP inhibitor scaffold containing an oxazolidinone core.Entities:
Keywords: CETP; Cholesteryl ester transfer protein; HDL; cardiovascular disease; high density lipoprotein; oxazolidinone
Year: 2011 PMID： 24900324 PMCID： PMC4018150 DOI： 10.1021/ml100309n
Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345