Literature DB >> 24900207

KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue.

Hiroyuki Yamakoshi1, Naoki Kanoh1, Chieko Kudo2, Atsuko Sato2, Kazunori Ueda1, Makoto Muroi3, Shunsuke Kon2, Masanobu Satake2, Hisatsugu Ohori2, Chikashi Ishioka2, Yoshiteru Oshima1, Hiroyuki Osada3, Natsuko Chiba2, Hiroyuki Shibata4, Yoshiharu Iwabuchi1.   

Abstract

Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.

Entities:  

Keywords:  KSRP/FUBP2; anticancer; bis(arylmethylidene)acetone; c-Myc; curcumin analogue; target protein

Year:  2010        PMID： 24900207      PMCID： PMC4007841          DOI： 10.1021/ml1000454

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  20 in total

1.  The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression.

Authors:  Juhong Liu; Fedor Kouzine; Zuqin Nie; Hye-Jung Chung; Zichrini Elisha-Feil; Achim Weber; Keji Zhao; David Levens
Journal:  EMBO J       Date:  2006-04-20       Impact factor: 11.598

2.  A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

Authors:  H Min; C W Turck; J M Nikolic; D L Black
Journal:  Genes Dev       Date:  1997-04-15       Impact factor: 11.361

3.  Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.

Authors:  Takayuki Teruya; Siro Simizu; Naoki Kanoh; Hiroyuki Osada
Journal:  FEBS Lett       Date:  2005-04-25       Impact factor: 4.124

4.  Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.

Authors:  Hiroyuki Shibata; Hiroyuki Yamakoshi; Atsuko Sato; Hisatsugu Ohori; Yuichi Kakudo; Chieko Kudo; Yayoi Takahashi; Mika Watanabe; Hiroshi Takano; Chikashi Ishioka; Tetsuo Noda; Yoshiharu Iwabuchi
Journal:  Cancer Sci       Date:  2009-05       Impact factor: 6.716

5.  Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA.

Authors:  Megan P Hall; Sui Huang; Douglas L Black
Journal:  Mol Biol Cell       Date:  2003-12-02       Impact factor: 4.138

6.  Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.

Authors:  Aiming Sun; Yang J Lu; Haipeng Hu; Mamoru Shoji; Dennis C Liotta; James P Snyder
Journal:  Bioorg Med Chem Lett       Date:  2009-10-08       Impact factor: 2.823

7.  Synthesis and evaluation of electron-rich curcumin analogues.

Authors:  Michael W Amolins; Laura B Peterson; Brian S J Blagg
Journal:  Bioorg Med Chem       Date:  2008-10-29       Impact factor: 3.641

8.  Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents.

Authors:  Brian K Adams; Eva M Ferstl; Matthew C Davis; Marike Herold; Serdar Kurtkaya; Richard F Camalier; Melinda G Hollingshead; Gurmeet Kaur; Edward A Sausville; Frederick R Rickles; James P Snyder; Dennis C Liotta; Mamoru Shoji
Journal:  Bioorg Med Chem       Date:  2004-07-15       Impact factor: 3.641

9.  2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver carcinogenesis.

Authors:  Ramdzan M Zubaidah; Gek San Tan; Sandra B E Tan; Seng Gee Lim; Qingsong Lin; Maxey C M Chung
Journal:  Proteomics       Date:  2008-12       Impact factor: 3.984

10.  The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

Authors:  Michele Trabucchi; Paola Briata; Mariaflor Garcia-Mayoral; Astrid D Haase; Witold Filipowicz; Andres Ramos; Roberto Gherzi; Michael G Rosenfeld
Journal:  Nature       Date:  2009-05-20       Impact factor: 49.962
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  5 in total

1.  Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death.

Authors:  Michael W Robinson; Jean H Overmeyer; Ashley M Young; Paul W Erhardt; William A Maltese
Journal:  J Med Chem       Date:  2012-02-28       Impact factor: 7.446

2.  Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.

Authors:  Andrew Brown; Qi Shi; Terry W Moore; Younghyoun Yoon; Andrew Prussia; Clinton Maddox; Dennis C Liotta; Hyunsuk Shim; James P Snyder
Journal:  J Med Chem       Date:  2013-04-23       Impact factor: 7.446

3.  Curcumin analog, GO-Y078, overcomes resistance to tumor angiogenesis inhibitors.

Authors:  Kazuhiro Shimazu; Masahiro Inoue; Shunsuke Sugiyama; Koji Fukuda; Taichi Yoshida; Daiki Taguchi; Yoshihiko Uehara; Sei Kuriyama; Masamitsu Tanaka; Masatomo Miura; Hiroshi Nanjyo; Yoshiharu Iwabuchi; Hiroyuki Shibata
Journal:  Cancer Sci       Date:  2018-08-16       Impact factor: 6.716

4.  Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma.

Authors:  Dumnoensun Pruksakorn; Pimpisa Teeyakasem; Jeerawan Klangjorhor; Parunya Chaiyawat; Jongkolnee Settakorn; Penchatr Diskul-Na-Ayudthaya; Daranee Chokchaichamnankit; Peraphan Pothacharoen; Chantragan Srisomsap
Journal:  Int J Oncol       Date:  2016-07-04       Impact factor: 5.650

Review 5.  RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate.

Authors:  Sofía M García-Mauriño; Francisco Rivero-Rodríguez; Alejandro Velázquez-Cruz; Marian Hernández-Vellisca; Antonio Díaz-Quintana; Miguel A De la Rosa; Irene Díaz-Moreno
Journal:  Front Mol Biosci       Date:  2017-10-23
  5 in total

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