Literature DB >> 24900183

Highly Selective Inhibitors of Class II Microbial Fructose Bis-phosphate Aldolases.

Racha Daher1, Michel Therisod1.   

Abstract

We hereby describe the rationale synthesis and biochemical evaluation of the most powerful and selective inhibitors of class II fructose bis-phosphate aldolases so far reported. These inhibitors are of potential therapeutic interest, since the class II enzyme is present exclusively in microorganisms (among which many pathogenic species) and is absent from man, plants, and animals.

Entities:  

Keywords:  Selective inhibitors; antibiotics; fructose bis-phosphate aldolase; glycolysis; metallo-enzymes; microbial enzymes

Year:  2010        PMID： 24900183      PMCID： PMC4007796          DOI： 10.1021/ml100017c

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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