Eugene Jeong1, Sun Young Oh1, Kisoo Pahk1, Chan-Nyoung Lee2, Kun-Woo Park2, Jae Sung Lee3, Gi Jeong Cheon4, Jae Gol Choe1. 1. Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea. 2. Department of Neurology, Korea University Medical Center, Seoul, Korea. 3. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. 4. Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea ; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
PURPOSE: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. METHODS: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. RESULTS: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. CONCLUSIONS: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.
PURPOSE: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. METHODS: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. RESULTS: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. CONCLUSIONS: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.
Authors: J O Rinne; H Ruottinen; J Bergman; M Haaparanta; P Sonninen; O Solin Journal: J Neurol Neurosurg Psychiatry Date: 1999-12 Impact factor: 10.154
Authors: S J Ortega Lozano; M D Martinez Del Valle Torres; E Ramos Moreno; S Sanz Viedma; T Amrani Raissouni; J M Jiménez-Hoyuela Journal: Rev Esp Med Nucl Date: 2010-07-23
Authors: S Asenbaum; T Brücke; W Pirker; I Podreka; P Angelberger; S Wenger; C Wöber; C Müller; L Deecke Journal: J Nucl Med Date: 1997-01 Impact factor: 10.057
Authors: Minyoung Oh; Jae Seung Kim; Ji Young Kim; Kwang-Ho Shin; Seol Hoon Park; Hye Ok Kim; Dae Hyuk Moon; Seung Jun Oh; Sun Ju Chung; Chong Sik Lee Journal: J Nucl Med Date: 2012-02-09 Impact factor: 10.057
Authors: Jin Su Kim; Hanna Cho; Jae Yong Choi; Seung Ha Lee; Young Hoon Ryu; Chul Hyoung Lyoo; Myung Sik Lee Journal: PLoS One Date: 2015-07-06 Impact factor: 3.240