PURPOSE: Individuals with systemic autoimmune disease have an increased susceptibility to both inflammation and malignancy. The aim of this study was to evaluate the clinical usefulness of (18)F-FDG PET/CT in patients with systemic autoimmune disease. METHODS: Forty patients diagnosed with systemic autoimmune disease were enrolled. Diagnostic accuracy of FDG PET/CT for detecting malignancy was assessed. FDG PET/CT findings, including maximum standardized uptake (SUVmax) of lymphadenopathy (LAP), liver, bone marrow, spleen, joint and muscles, were considered for the characterization of LAPs. RESULTS: FDG PET/CT could detect metabolically activated lesions in 36 out of 40 patients (90%) including inflammatory lesions in 28 out of 32 patients (88%). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG PET/CT for the detection of malignancy were 100, 67, 70, 25, and 100%, respectively. Multiple LAPs were found in 25 of 40 patients (63%), and comprised three malignancies, four cases of tuberculosis, and 18 reactive changes. A SUVmax ratio of bone marrow to liver below 0.78 could distinguish malignancy from tuberculosis + reactive change (AUC = 1.000, sensitivity: 100%, specificity: 100%). The SUVmax ratio of spleen to liver in the reactive group was also significantly higher than that in the malignancy group (P = 0.014). SUVmax of LAP in the TB group was significantly higher than that in the reactive group (P = 0.040). CONCLUSIONS: PET/CT is useful in detecting and differentiating inflammation and malignancy in patients with systemic autoimmune disease. Frequent false-positive interpretations can be minimized by consideration of FDG uptake in bone marrow and spleen.
PURPOSE: Individuals with systemic autoimmune disease have an increased susceptibility to both inflammation and malignancy. The aim of this study was to evaluate the clinical usefulness of (18)F-FDG PET/CT in patients with systemic autoimmune disease. METHODS: Forty patients diagnosed with systemic autoimmune disease were enrolled. Diagnostic accuracy of FDG PET/CT for detecting malignancy was assessed. FDG PET/CT findings, including maximum standardized uptake (SUVmax) of lymphadenopathy (LAP), liver, bone marrow, spleen, joint and muscles, were considered for the characterization of LAPs. RESULTS:FDG PET/CT could detect metabolically activated lesions in 36 out of 40 patients (90%) including inflammatory lesions in 28 out of 32 patients (88%). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG PET/CT for the detection of malignancy were 100, 67, 70, 25, and 100%, respectively. Multiple LAPs were found in 25 of 40 patients (63%), and comprised three malignancies, four cases of tuberculosis, and 18 reactive changes. A SUVmax ratio of bone marrow to liver below 0.78 could distinguish malignancy from tuberculosis + reactive change (AUC = 1.000, sensitivity: 100%, specificity: 100%). The SUVmax ratio of spleen to liver in the reactive group was also significantly higher than that in the malignancy group (P = 0.014). SUVmax of LAP in the TB group was significantly higher than that in the reactive group (P = 0.040). CONCLUSIONS: PET/CT is useful in detecting and differentiating inflammation and malignancy in patients with systemic autoimmune disease. Frequent false-positive interpretations can be minimized by consideration of FDG uptake in bone marrow and spleen.
Authors: Dalton Alexandre dos Anjos; Georges Ferreira do Vale; Cejana de Mello Campos; Leonardo Fonseca Monteiro do Prado; Alaor Barra Sobrinho; Alexandre Lima Rodrigues da Cunha; Anna Carolina Moraes Santos Journal: Clin Nucl Med Date: 2010-07 Impact factor: 7.794
Authors: Ernst H Elzinga; Conny J van der Laken; Emile F I Comans; Ronald Boellaard; Otto S Hoekstra; Ben A C Dijkmans; Adriaan A Lammertsma; Alexandre E Voskuyl Journal: J Nucl Med Date: 2010-12-13 Impact factor: 10.057
Authors: Miroslawa Nowak; Jorge A Carrasquillo; Cheryl H Yarboro; Steven L Bacharach; Millie Whatley; Xavier Valencia; Kazuki Takada; Douglas G Brust; Gabor G Illei Journal: Arthritis Rheum Date: 2004-04
Authors: Pierre Y Salaun; Thomas Gastinne; Caroline Bodet-Milin; Loïc Campion; Pierre Cambefort; Anne Moreau; Steven Le Gouill; Christian Berthou; Philippe Moreau; Françoise Kraeber-Bodéré Journal: Eur J Nucl Med Mol Imaging Date: 2009-06-05 Impact factor: 9.236
Authors: Jun Zhang; Meng-Jie Dong; Kan-Feng Liu; Li-Ming Xu; Kui Zhao; Jun Yang; Wan-Wen Weng; Hong Qiu; Li-Li Lin; Yang-Jun Zhu Journal: Int J Clin Exp Med Date: 2015-11-15