Young Chul Kim1, Yun Hwan Kim2, Soon Ho Um3, Yeon Seok Seo3, Eun Kyung Park1, Sun Young Oh1, You Mie Han4, Jae-Gol Choe5. 1. Department of Nuclear Medicine, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea. 2. Department of Radiology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea. 3. Department of Internal Medicine, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea. 4. Department of Radiology, College of Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea. 5. Department of Nuclear Medicine, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea ; Department of Nuclear Medicine, Korea University Anam Hospital, 126-1 Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705 South Korea.
Abstract
PURPOSE: Y-90 resin microsphere radioembolization is used to treat inoperable hepatic tumors. After injection of Y-90 resin microsphere, the only method to visualize the distribution of Y-90 is the scintigraphic imaging of bremsstrahlung radiation. The purpose of this study was to evaluate the characteristics and usefulness of bremsstrahlung imaging in Y-90 resin microsphere treatment. METHODS: Twenty patients (22 administrations) underwent intra-arterial Y-90 resin microsphere treatment. For pre-treatment planning, images of Tc-99m albumin macroaggregate (MAA) arterial injection and hepatic contrast angiography were obtained. Post-treatment bremsstrahlung images were taken and compared with pre-treatment images. The extrahepatic activity was evaluated on bremsstrahlung images. To correlate the size and vascularity of the tumors with tumor visualization on bremsstrahlung images, the individual tumors were grouped according to visualization on each image and compared with one another by size and tumor-to-normal ratio. RESULTS: All post-therapeutic bremsstrahlung images showed similar contours of the liver with pre-treatment angiography. No extrahepatic activity was seen in all cases. The visualized tumors on bremsstrahlung images were significantly larger than the non-visualized tumors. Tumor-to-normal ratios of the visualized tumors on bremsstrahlung images were significantly higher than those of the non-visualized tumors. CONCLUSIONS: Bremsstrahlung images after intra-arterial Y-90 resin microsphere treatment are useful in evaluating the intrahepatic distribution of radioisotope and detecting possible extrahepatic activity.
PURPOSE:Y-90 resin microsphere radioembolization is used to treat inoperable hepatic tumors. After injection of Y-90 resin microsphere, the only method to visualize the distribution of Y-90 is the scintigraphic imaging of bremsstrahlung radiation. The purpose of this study was to evaluate the characteristics and usefulness of bremsstrahlung imaging in Y-90 resin microsphere treatment. METHODS: Twenty patients (22 administrations) underwent intra-arterial Y-90 resin microsphere treatment. For pre-treatment planning, images of Tc-99m albumin macroaggregate (MAA) arterial injection and hepatic contrast angiography were obtained. Post-treatment bremsstrahlung images were taken and compared with pre-treatment images. The extrahepatic activity was evaluated on bremsstrahlung images. To correlate the size and vascularity of the tumors with tumor visualization on bremsstrahlung images, the individual tumors were grouped according to visualization on each image and compared with one another by size and tumor-to-normal ratio. RESULTS: All post-therapeutic bremsstrahlung images showed similar contours of the liver with pre-treatment angiography. No extrahepatic activity was seen in all cases. The visualized tumors on bremsstrahlung images were significantly larger than the non-visualized tumors. Tumor-to-normal ratios of the visualized tumors on bremsstrahlung images were significantly higher than those of the non-visualized tumors. CONCLUSIONS: Bremsstrahlung images after intra-arterial Y-90 resin microsphere treatment are useful in evaluating the intrahepatic distribution of radioisotope and detecting possible extrahepatic activity.
Authors: Andrew S Kennedy; Douglas Coldwell; Charles Nutting; Ravi Murthy; Daniel E Wertman; Stephen P Loehr; Carroll Overton; Steven Meranze; Jerry Niedzwiecki; Scott Sailer Journal: Int J Radiat Oncol Biol Phys Date: 2006-06-01 Impact factor: 7.038
Authors: Guy Van Hazel; Anthony Blackwell; James Anderson; David Price; Paul Moroz; Geoff Bower; Giuseppe Cardaci; Bruce Gray Journal: J Surg Oncol Date: 2004-11-01 Impact factor: 3.454
Authors: Ravi Murthy; Rodolfo Nunez; Janio Szklaruk; William Erwin; David C Madoff; Sanjay Gupta; Kamran Ahrar; Michael J Wallace; Alan Cohen; Douglas M Coldwell; Andrew S Kennedy; Marshall E Hicks Journal: Radiographics Date: 2005-10 Impact factor: 5.333
Authors: T W Leung; W Y Lau; S K Ho; S C Ward; J H Chow; M S Chan; C Metreweli; P J Johnson; A K Li Journal: Int J Radiat Oncol Biol Phys Date: 1995-11-01 Impact factor: 7.038
Authors: Clinton D Crowder; Carol Grabowski; Subbarao Inampudi; Timothy Sielaff; Cynthia A Sherman; Kenneth P Batts Journal: Am J Surg Pathol Date: 2009-07 Impact factor: 6.394
Authors: Ricky A Sharma; Guy A Van Hazel; Bruno Morgan; David P Berry; Keith Blanshard; David Price; Geoffrey Bower; Jennifer A Shannon; Peter Gibbs; William P Steward Journal: J Clin Oncol Date: 2007-03-20 Impact factor: 44.544
Authors: Ravi Murthy; Daniel B Brown; Riad Salem; Steven G Meranze; Douglas M Coldwell; Sunil Krishnan; Rodolfo Nunez; Amit Habbu; David Liu; William Ross; Alan M Cohen; Michael Censullo Journal: J Vasc Interv Radiol Date: 2007-04 Impact factor: 3.464
Authors: Mohammad Elsayed; Mohammad Loya; James Galt; David M Schuster; Zachary L Bercu; Janice Newsome; David Brandon; Sonia Benenati; Keywan Behbahani; Richard Duszak; Ila Sethi; Nima Kokabi Journal: World J Gastrointest Oncol Date: 2021-05-15