Literature DB >> 24899206

Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.

Adam R Hersperger1, Nicholas A Siciliano2, Brian C DeHaven2, Adam E Snook2, Laurence C Eisenlohr3.   

Abstract

We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8(+) T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24899206      PMCID： PMC4136261          DOI： 10.1128/JVI.01464-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  Control of mouse pox (infectious ectromelia) by immunization with vaccinia virus.

Authors:  J J TRENTIN; M A FERRIGNO
Journal:  J Natl Cancer Inst       Date:  1957-05       Impact factor: 13.506

2.  The relationship between the virus of infectious ectromelia of mice and vaccinia virus.

Authors:  F M BURNET; W C BOAKE
Journal:  J Immunol       Date:  1946-05       Impact factor: 5.422

Review 3.  Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection.

Authors:  George Makedonas; Michael R Betts
Journal:  Springer Semin Immunopathol       Date:  2006-08-25

Review 4.  T-cell quality in memory and protection: implications for vaccine design.

Authors:  Robert A Seder; Patricia A Darrah; Mario Roederer
Journal:  Nat Rev Immunol       Date:  2008-03-07       Impact factor: 53.106

5.  Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus.

Authors:  Thomas Gebhardt; Linda M Wakim; Liv Eidsmo; Patrick C Reading; William R Heath; Francis R Carbone
Journal:  Nat Immunol       Date:  2009-03-22       Impact factor: 25.606

6.  Studies in infectious ectromelia of mice; immunization of mice against ectromelia with living vaccinia virus.

Authors:  F FENNER
Journal:  Aust J Exp Biol Med Sci       Date:  1947-09

7.  Antiviral protection following immunization correlates with humoral but not cell-mediated immunity.

Authors:  Vijay Panchanathan; Geeta Chaudhri; Gunasegaran Karupiah
Journal:  Immunol Cell Biol       Date:  2010-01-12       Impact factor: 5.126

8.  HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.

Authors:  Michael R Betts; Martha C Nason; Sadie M West; Stephen C De Rosa; Stephen A Migueles; Jonathan Abraham; Michael M Lederman; Jose M Benito; Paul A Goepfert; Mark Connors; Mario Roederer; Richard A Koup
Journal:  Blood       Date:  2006-02-07       Impact factor: 22.113

9.  Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.

Authors:  Xiaodong Jiang; Rachael A Clark; Luzheng Liu; Amy J Wagers; Robert C Fuhlbrigge; Thomas S Kupper
Journal:  Nature       Date:  2012-02-29       Impact factor: 49.962

10.  Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.

Authors:  Luzheng Liu; Qiong Zhong; Tian Tian; Krista Dubin; Shruti K Athale; Thomas S Kupper
Journal:  Nat Med       Date:  2010-01-17       Impact factor: 53.440
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  6 in total

Review 1.  Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus.

Authors:  Samuel J Hobbs; Jossef F Osborn; Jeffrey C Nolz
Journal:  Curr Opin Virol       Date:  2017-10-25       Impact factor: 7.090

2.  Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox.

Authors:  Tiffany R Frey; Katherine S Forsyth; Maura M Sheehan; Brian C De Haven; Julia G Pevarnik; Erin S Hand; Marie C Pizzorno; Laurence C Eisenlohr; Adam R Hersperger
Journal:  Virology       Date:  2018-03-27       Impact factor: 3.616

Review 3.  Anti-viral protective capacity of tissue resident memory T cells.

Authors:  Daniel H Paik; Donna L Farber
Journal:  Curr Opin Virol       Date:  2020-10-30       Impact factor: 7.090

4.  An increase in glycoprotein concentration on extracellular virions dramatically alters vaccinia virus infectivity and pathogenesis without impacting immunogenicity.

Authors:  Stephanie R Monticelli; Peter Bryk; Matthew G Brewer; Hector C Aguilar; Christopher C Norbury; Brian M Ward
Journal:  PLoS Pathog       Date:  2021-12-28       Impact factor: 6.823

5.  Development of improved therapeutic mesothelin-based vaccines for pancreatic cancer.

Authors:  Michael White; Andrew Freistaedter; Gwendolyn J B Jones; Emmanuel Zervos; Rachel L Roper
Journal:  PLoS One       Date:  2018-02-23       Impact factor: 3.240

6.  A Systematic Review: The Role of Resident Memory T Cells in Infectious Diseases and Their Relevance for Vaccine Development.

Authors:  Visai Muruganandah; Harindra D Sathkumara; Severine Navarro; Andreas Kupz
Journal:  Front Immunol       Date:  2018-07-09       Impact factor: 7.561
  6 in total

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