UNLABELLED: Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in the treatment of Paget disease. We retrospectively reviewed remission and relapse statuses of 12 patients with Paget disease. Remission was achieved in all patients after treatment. We recommend zoledronic acid in the first-line treatment of Paget disease. INTRODUCTION: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in the treatment of Paget disease. METHODS: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Paget disease of bone who were seen as outpatients between October 2011 and October 2013.We evaluated alkaline phosphates, osteocalcin, and deoxypyridinoline levels measured before and at 6th, 12th, and 18th months of treatment. RESULTS: Pretreatment and posttreatment values for alkaline phosphates, deoxypyridinoline, and osteocalcin were as follows: 473 ± 256 U/L, 14.99 ± 7.63 mmol/L, 21.09 ± 3.18 ng/ml, and 82 ± 13 U/L, 5.14 ± 1.11 mmol/L, and 8.57 ± 4.31 ng/ml. Remission was achieved in all patients after treatment. The levels indicated that remission continued at 12th and 18th months of treatment. There was statistically significant difference between pretreatment and posttreatment values. No statistically significant difference between the levels measured at 6th, 12th, and 18th months of treatment was detected. CONCLUSION: We recommend zoledronic acid in the first-line treatment of Paget disease of bone in achieving and maintaining remission.
UNLABELLED: Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in the treatment of Paget disease. We retrospectively reviewed remission and relapse statuses of 12 patients with Paget disease. Remission was achieved in all patients after treatment. We recommend zoledronic acid in the first-line treatment of Paget disease. INTRODUCTION: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in the treatment of Paget disease. METHODS: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Paget disease of bone who were seen as outpatients between October 2011 and October 2013.We evaluated alkaline phosphates, osteocalcin, and deoxypyridinoline levels measured before and at 6th, 12th, and 18th months of treatment. RESULTS: Pretreatment and posttreatment values for alkaline phosphates, deoxypyridinoline, and osteocalcin were as follows: 473 ± 256 U/L, 14.99 ± 7.63 mmol/L, 21.09 ± 3.18 ng/ml, and 82 ± 13 U/L, 5.14 ± 1.11 mmol/L, and 8.57 ± 4.31 ng/ml. Remission was achieved in all patients after treatment. The levels indicated that remission continued at 12th and 18th months of treatment. There was statistically significant difference between pretreatment and posttreatment values. No statistically significant difference between the levels measured at 6th, 12th, and 18th months of treatment was detected. CONCLUSION: We recommend zoledronic acid in the first-line treatment of Paget disease of bone in achieving and maintaining remission.
Authors: Ian R Reid; Kenneth Lyles; Guoqin Su; Jacques P Brown; John P Walsh; Javier del Pino-Montes; Paul D Miller; William D Fraser; Susan Cafoncelli; Christina Bucci-Rechtweg; David J Hosking Journal: J Bone Miner Res Date: 2011-09 Impact factor: 6.741
Authors: G H Nancollas; R Tang; R J Phipps; Z Henneman; S Gulde; W Wu; A Mangood; R G G Russell; F H Ebetino Journal: Bone Date: 2005-07-20 Impact factor: 4.398
Authors: I R Reid; G C Nicholson; R S Weinstein; D J Hosking; T Cundy; M A Kotowicz; W A Murphy; S Yeap; S Dufresne; A Lombardi; T A Musliner; D E Thompson; A J Yates Journal: Am J Med Date: 1996-10 Impact factor: 4.965
Authors: Ian R Reid; Paul Miller; Kenneth Lyles; William Fraser; Jacques P Brown; Youssef Saidi; Peter Mesenbrink; Guoqin Su; Judy Pak; Ken Zelenakas; Monica Luchi; Peter Richardson; David Hosking Journal: N Engl J Med Date: 2005-09-01 Impact factor: 91.245
Authors: David Hosking; Kenneth Lyles; Jacques P Brown; William D Fraser; Paul Miller; Manuel Diaz Curiel; Jean-Pierre Devogelaer; Michael Hooper; Guoqin Su; Ken Zelenakas; Judy Pak; Taiwo Fashola; Youssef Saidi; Erik Fink Eriksen; Ian R Reid Journal: J Bone Miner Res Date: 2007-01 Impact factor: 6.741