Literature DB >> 24898818

Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.

Houda Benrahma1, Hicham Charoute, Khaled Lasram, Redouane Boulouiz, Rym Kefi-Ben Atig, Malika Fakiri, Hassan Rouba, Sonia Abdelhak, Abdelhamid Barakat.   

Abstract

Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.

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Year:  2014        PMID： 24898818     DOI： 10.1007/s10528-014-9658-5

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  10 in total

Review 1.  The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers.

Authors:  Jinyan Wang; Lijuan Chen; Ping Qiang
Journal:  Cancer Cell Int       Date:  2021-02-10       Impact factor: 5.722

2.  Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage.

Authors:  Alba Casellas; Cristina Mallol; Ariana Salavert; Veronica Jimenez; Miquel Garcia; Judith Agudo; Mercè Obach; Virginia Haurigot; Laia Vilà; Maria Molas; Ricardo Lage; Meritxell Morró; Estefania Casana; Jesús Ruberte; Fatima Bosch
Journal:  J Biol Chem       Date:  2015-05-13       Impact factor: 5.157

3.  Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling.

Authors:  Andrew D Bailey; Jason Talkish; Hongxu Ding; Haller Igel; Alejandra Duran; Shreya Mantripragada; Benedict Paten; Manuel Ares
Journal:  Elife       Date:  2022-04-06       Impact factor: 8.713

Review 4.  Role of GNB3, NET, KCNJ11, TCF7L2 and GRL genes single nucleotide polymorphism in the risk prediction of type 2 diabetes mellitus.

Authors:  Saliha Rizvi; Syed Tasleem Raza; Qamar Rahman; Farzana Mahdi
Journal:  3 Biotech       Date:  2016-12-02       Impact factor: 2.406

Review 5.  The RNA modification landscape in human disease.

Authors:  Nicky Jonkhout; Julia Tran; Martin A Smith; Nicole Schonrock; John S Mattick; Eva Maria Novoa
Journal:  RNA       Date:  2017-08-30       Impact factor: 4.942

6.  Association of KCNJ11 rs5219 gene polymorphism with type 2 diabetes mellitus in a population of Syria: a case-control study.

Authors:  Osama Makhzoom; Younes Kabalan; Faizeh Al-Quobaili
Journal:  BMC Med Genet       Date:  2019-06-13       Impact factor: 2.103

7.  Mapping of Diabetes Susceptibility Loci in a Domestic Cat Breed with an Unusually High Incidence of Diabetes Mellitus.

Authors:  Lois Balmer; Caroline Ann O'Leary; Marilyn Menotti-Raymond; Victor David; Stephen O'Brien; Belinda Penglis; Sher Hendrickson; Mia Reeves-Johnson; Susan Gottlieb; Linda Fleeman; Dianne Vankan; Jacquie Rand; Grant Morahan
Journal:  Genes (Basel)       Date:  2020-11-19       Impact factor: 4.096

8.  A 1000 Arab genome project to study the Emirati population.

Authors:  Mariam Al-Ali; Wael Osman; Guan K Tay; Habiba S AlSafar
Journal:  J Hum Genet       Date:  2018-02-06       Impact factor: 3.172

9.  Genes associated with Type 2 Diabetes and vascular complications.

Authors:  Alberto Montesanto; Anna Rita Bonfigli; Roberto Testa; Fabiola Olivieri; Giuseppina Rose; Paolina Crocco; Paolo Garagnani; Maria De Luca; Massimo Boemi; Elena Marasco; Chiara Pirazzini; Cristina Giuliani; Claudio Franceschi; Giuseppe Passarino
Journal:  Aging (Albany NY)       Date:  2018-02-04       Impact factor: 5.682

10.  Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians.

Authors:  Dalia El-Lebedy; Ingy Ashmawy
Journal:  J Genet Eng Biotechnol       Date:  2016-11-05
  10 in total

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