Literature DB >> 24898748

Strategies for cardiac regeneration and repair.

Zhiqiang Lin1, William T Pu2.   

Abstract

Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining cardiomyocytes but are unable to overcome the fundamental problem of regenerating lost cardiomyocytes. Several strategies for promoting heart regeneration have emerged from decades of intensive study. Although some of these strategies remain confined to basic research, others are beginning to be tested in humans. We review strategies for cardiac regeneration and summarize progress of related clinical trials.
Copyright © 2014, American Association for the Advancement of Science.

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Year:  2014        PMID： 24898748      PMCID： PMC4280908          DOI： 10.1126/scitranslmed.3006681

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  105 in total

1.  Soluble factors from multipotent mesenchymal stromal cells have antinecrotic effect on cardiomyocytes in vitro and improve cardiac function in infarcted rat hearts.

Authors:  P Fidelis-de-Oliveira; J P S Werneck-de-Castro; V Pinho-Ribeiro; B C M Shalom; J H Nascimento-Silva; R H Costa e Souza; I S Cruz; R R Rangel; R C S Goldenberg; A C Campos-de-Carvalho
Journal:  Cell Transplant       Date:  2012-02-02       Impact factor: 4.064

2.  Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.

Authors:  Jose Francisco Islas; Yu Liu; Kuo-Chan Weng; Matthew J Robertson; Shuxing Zhang; Allan Prejusa; John Harger; Dariya Tikhomirova; Mani Chopra; Dinakar Iyer; Mark Mercola; Robert G Oshima; James T Willerson; Vladimir N Potaman; Robert J Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-23       Impact factor: 11.205

3.  Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts.

Authors:  Michael A Laflamme; David Myerson; Jeffrey E Saffitz; Charles E Murry
Journal:  Circ Res       Date:  2002-04-05       Impact factor: 17.367

Review 4.  The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway.

Authors:  Wanjin Hong; Kun-Liang Guan
Journal:  Semin Cell Dev Biol       Date:  2012-05-29       Impact factor: 7.727

Review 5.  Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease.

Authors:  Alexander von Gise; William T Pu
Journal:  Circ Res       Date:  2012-06-08       Impact factor: 17.367

6.  Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance.

Authors:  Atul R Chugh; Garth M Beache; John H Loughran; Nathan Mewton; Julius B Elmore; Jan Kajstura; Patroklos Pappas; Antone Tatooles; Marcus F Stoddard; Joao A C Lima; Mark S Slaughter; Piero Anversa; Roberto Bolli
Journal:  Circulation       Date:  2012-09-11       Impact factor: 29.690

7.  Cardiomyogenesis in the aging and failing human heart.

Authors:  Jan Kajstura; Marcello Rota; Donato Cappetta; Barbara Ogórek; Christian Arranto; Yingnan Bai; João Ferreira-Martins; Sergio Signore; Fumihiro Sanada; Alex Matsuda; James Kostyla; Maria-Virginia Caballero; Claudia Fiorini; David A D'Alessandro; Robert E Michler; Federica del Monte; Toru Hosoda; Mark A Perrella; Annarosa Leri; Bruce A Buchholz; Joseph Loscalzo; Piero Anversa
Journal:  Circulation       Date:  2012-09-06       Impact factor: 29.690

8.  Heart repair by reprogramming non-myocytes with cardiac transcription factors.

Authors:  Kunhua Song; Young-Jae Nam; Xiang Luo; Xiaoxia Qi; Wei Tan; Guo N Huang; Asha Acharya; Christopher L Smith; Michelle D Tallquist; Eric G Neilson; Joseph A Hill; Rhonda Bassel-Duby; Eric N Olson
Journal:  Nature       Date:  2012-05-13       Impact factor: 49.962

9.  In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.

Authors:  Li Qian; Yu Huang; C Ian Spencer; Amy Foley; Vasanth Vedantham; Lei Liu; Simon J Conway; Ji-dong Fu; Deepak Srivastava
Journal:  Nature       Date:  2012-05-31       Impact factor: 49.962

10.  Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts.

Authors:  Yuji Shiba; Sarah Fernandes; Wei-Zhong Zhu; Dominic Filice; Veronica Muskheli; Jonathan Kim; Nathan J Palpant; Jay Gantz; Kara White Moyes; Hans Reinecke; Benjamin Van Biber; Todd Dardas; John L Mignone; Atsushi Izawa; Ramy Hanna; Mohan Viswanathan; Joseph D Gold; Michael I Kotlikoff; Narine Sarvazyan; Matthew W Kay; Charles E Murry; Michael A Laflamme
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962
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  56 in total

1.  Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair.

Authors:  Zhenhua Li; Deliang Shen; Shiqi Hu; Teng Su; Ke Huang; Feiran Liu; Lei Hou; Ke Cheng
Journal:  ACS Nano       Date:  2018-12-04       Impact factor: 15.881

2.  Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.

Authors:  Brian D Polizzotti; Balakrishnan Ganapathy; Stuart Walsh; Sangita Choudhury; Niyatie Ammanamanchi; David G Bennett; Cristobal G dos Remedios; Bernhard J Haubner; Josef M Penninger; Bernhard Kühn
Journal:  Sci Transl Med       Date:  2015-04-01       Impact factor: 17.956

Review 3.  Redirecting cardiac growth mechanisms for therapeutic regeneration.

Authors:  Ravi Karra; Kenneth D Poss
Journal:  J Clin Invest       Date:  2017-02-01       Impact factor: 14.808

4.  Generation of new cardiomyocytes after injury: de novo formation from resident progenitors vs. replication of pre-existing cardiomyocytes.

Authors:  Daniele Torella; Ciro Indolfi; Bernardo Nadal-Ginard
Journal:  Ann Transl Med       Date:  2015-05

Review 5.  Targeting the hedgehog signaling pathway for cardiac repair and regeneration.

Authors:  Y Wang; P Lu; D Zhao; J Sheng
Journal:  Herz       Date:  2016-11-22       Impact factor: 1.443

Review 6.  Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.

Authors:  Jessie Wettig Yester; Bernhard Kühn
Journal:  Curr Cardiol Rep       Date:  2017-02       Impact factor: 2.931

7.  Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy.

Authors:  Vasileios Karantalis; Viky Y Suncion-Loescher; Luiza Bagno; Samuel Golpanian; Ariel Wolf; Cristina Sanina; Courtney Premer; Anthony J Kanelidis; Frederic McCall; Bo Wang; Wayne Balkan; Jose Rodriguez; Marcos Rosado; Azorides Morales; Konstantinos Hatzistergos; Makoto Natsumeda; Irene Margitich; Ivonne Hernandez Schulman; Samirah A Gomes; Muzammil Mushtaq; Darcy L DiFede; Joel E Fishman; Pradip Pattany; Juan Pablo Zambrano; Alan W Heldman; Joshua M Hare
Journal:  J Am Coll Cardiol       Date:  2015-11-03       Impact factor: 24.094

Review 8.  Chasing c-Kit through the heart: Taking a broader view.

Authors:  Natalie A Gude; Mark A Sussman
Journal:  Pharmacol Res       Date:  2017-06-13       Impact factor: 7.658

9.  Stimulatory Effects of Mesenchymal Stem Cells on cKit+ Cardiac Stem Cells Are Mediated by SDF1/CXCR4 and SCF/cKit Signaling Pathways.

Authors:  Konstantinos E Hatzistergos; Dieter Saur; Barbara Seidler; Wayne Balkan; Matthew Breton; Krystalenia Valasaki; Lauro M Takeuchi; Ana Marie Landin; Aisha Khan; Joshua M Hare
Journal:  Circ Res       Date:  2016-08-01       Impact factor: 17.367

10.  Biodegradable nanofibrous temperature-responsive gelling microspheres for heart regeneration.

Authors:  Chao Zhao; Shuo Tian; Qihai Liu; Kemao Xiu; Ienglam Lei; Zhong Wang; Peter X Ma
Journal:  Adv Funct Mater       Date:  2020-03-20       Impact factor: 18.808
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