Literature DB >> 24898703

Photobiological characteristics of chlorophyll a derivatives as microbial PDT agents.

Marciana P Uliana1, Layla Pires, Sebastião Pratavieira, Timothy J Brocksom, Kleber T de Oliveira, Vanderlei S Bagnato, Cristina Kurachi.   

Abstract

Chlorin-e6 (chl-e6) and a hydrogenated derivative (chl-e6H) were semi-synthesized, and their photophysical properties and photodynamic activity against Escherichia coli, Staphylococcus aureus and Candida albicans evaluated. Methyl pheophorbide-a (Mepheo-a) was obtained from S. maxima using methanolic extraction with acid catalysis (CH3OH–H2SO4). Chlorin-e6 was prepared from Mepheo-a by basic hydrolysis with H2O–acetone and NaOH. Hydrogenated Chlorin-e6 was synthesized by a similar procedure starting from the hydrogenated methyl pheophorbide-a (Mepheo-aH). Photophysical studies were performed in order to determine the singlet oxygen quantum yield of chl-e6H which is higher than that of chl-e6. The microorganism inactivation of chl-e6 and chl-e6H was investigated at two concentrations and three fluence levels. Both chl-e6 and chl-e6H showed microorganism inactivation against Gram-positive bacteria and a fungus.

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Year:  2014        PMID： 24898703     DOI： 10.1039/c3pp50376c

Source DB:  PubMed          Journal:  Photochem Photobiol Sci        ISSN： 1474-905X            Impact factor:   3.982


  7 in total

Review 1.  Efficacy of antimicrobial photodynamic therapy (aPDT) for nonsurgical treatment of periodontal disease: a systematic review.

Authors:  Marcella Goetz Moro; Veronica Franco de Carvalho; Bianca A Godoy-Miranda; Claudio Teruo Kassa; Anna Carolina Ratto Tempestini Horliana; Renato Araujo Prates
Journal:  Lasers Med Sci       Date:  2021-01-12       Impact factor: 3.161

2.  Biofilm formation by Candida albicans is inhibited by photodynamic antimicrobial chemotherapy (PACT), using chlorin e6: increase in both ROS production and membrane permeability.

Authors:  Moisés Lopes Carvalho; Ana Paula Pinto; Leandro José Raniero; Maricilia Silva Costa
Journal:  Lasers Med Sci       Date:  2017-10-09       Impact factor: 3.161

3.  Antimicrobial Photodynamic therapy enhanced by the peptide aurein 1.2.

Authors:  Laura Marise de Freitas; Esteban Nicolás Lorenzón; Norival Alves Santos-Filho; Lucas Henrique de Paula Zago; Marciana Pierina Uliana; Kleber Thiago de Oliveira; Eduardo Maffud Cilli; Carla Raquel Fontana
Journal:  Sci Rep       Date:  2018-03-09       Impact factor: 4.379

4.  Antibacterial Nanoparticles with Natural Photosensitizers Extracted from Spinach Leaves.

Authors:  Pavel Ludačka; Pavel Kubát; Zuzana Bosáková; Jiří Mosinger
Journal:  ACS Omega       Date:  2021-12-17

5.  Carboranyl-Chlorin e6 as a Potent Antimicrobial Photosensitizer.

Authors:  Elena O Omarova; Pavel A Nazarov; Alexander M Firsov; Marina G Strakhovskaya; Anastasia Yu Arkhipova; Mikhail M Moisenovich; Igor I Agapov; Valentina A Ol'shevskaya; Andrey V Zaitsev; Valery N Kalinin; Elena A Kotova; Yuri N Antonenko
Journal:  PLoS One       Date:  2015-11-04       Impact factor: 3.240

6.  Chlorophyll a Covalently Bonded to Organo-Modified Translucent Silica Xerogels: Optimizing Fluorescence and Maximum Loading.

Authors:  M A García-Sánchez; I N Serratos; R Sosa; T Tapia-Esquivel; F González-García; F Rojas-González; S R Tello-Solís; A Y Palacios-Enriquez; J M Esparza Schulz; A Arrieta
Journal:  Molecules       Date:  2016-07-22       Impact factor: 4.411

7.  Photodynamic therapy dosimetry using multiexcitation multiemission wavelength: toward real-time prediction of treatment outcome.

Authors:  Monirehalsadat Mousavi; Lilian Tan Moriyama; Clovis Grecco; Marcelo Saito Nogueira; Katarina Svanberg; Cristina Kurachi; Stefan Andersson-Engels
Journal:  J Biomed Opt       Date:  2020-04       Impact factor: 3.170
  7 in total

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