| Literature DB >> 24896819 |
Michael R Wilson1, Samia N Naccache, Erik Samayoa, Mark Biagtan, Hiba Bashir, Guixia Yu, Shahriar M Salamat, Sneha Somasekar, Scot Federman, Steve Miller, Robert Sokolic, Elizabeth Garabedian, Fabio Candotti, Rebecca H Buckley, Kurt D Reed, Teresa L Meyer, Christine M Seroogy, Renee Galloway, Sheryl L Henderson, James E Gern, Joseph L DeRisi, Charles Y Chiu.
Abstract
A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 sequence reads (0.016%) corresponding to leptospira infection. Clinical assays for leptospirosis were negative. Targeted antimicrobial agents were administered, and the patient was discharged home 32 days later with a status close to his premorbid condition. Polymerase-chain-reaction (PCR) and serologic testing at the Centers for Disease Control and Prevention (CDC) subsequently confirmed evidence of Leptospira santarosai infection.Entities:
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Year: 2014 PMID： 24896819 PMCID： PMC4134948 DOI： 10.1056/NEJMoa1401268
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245