Literature DB >> 24896568

Frizzled fissure to improve central nervous system drug delivery?

Lester R Drewes1.   

Abstract

Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-canonical Wnt signaling. Inhibition of this pathway leads to downregulation of P-glycoprotein and increased transcellular drug transport and reveals a potential strategy for improving drug delivery for treatment of neurologic diseases.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24896568      PMCID： PMC4126104          DOI： 10.1038/jcbfm.2014.98

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  7 in total

Review 1.  Wnt/beta-catenin signaling: components, mechanisms, and diseases.

Authors:  Bryan T MacDonald; Keiko Tamai; Xi He
Journal:  Dev Cell       Date:  2009-07       Impact factor: 12.270

Review 2.  Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain.

Authors:  Sagar Agarwal; Ramola Sane; Rajneet Oberoi; John R Ohlfest; William F Elmquist
Journal:  Expert Rev Mol Med       Date:  2011-05-13       Impact factor: 5.600

Review 3.  Drug transport across the blood-brain barrier.

Authors:  William M Pardridge
Journal:  J Cereb Blood Flow Metab       Date:  2012-08-29       Impact factor: 6.200

4.  Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors.

Authors:  Yasuo Uchida; Sumio Ohtsuki; Yuki Katsukura; Chiemi Ikeda; Takashi Suzuki; Junichi Kamiie; Tetsuya Terasaki
Journal:  J Neurochem       Date:  2011-02-25       Impact factor: 5.372

5.  Rho GTPase activity modulates Wnt3a/beta-catenin signaling.

Authors:  Jessica Rossol-Allison; Laura N Stemmle; Katherine I Swenson-Fields; Patrick Kelly; Patrick E Fields; Shannon J McCall; Patrick J Casey; Timothy A Fields
Journal:  Cell Signal       Date:  2009-05-29       Impact factor: 4.315

6.  The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells.

Authors:  Martha L Pinzón-Daza; Iris C Salaroglio; Joanna Kopecka; Ruth Garzòn; Pierre-Olivier Couraud; Dario Ghigo; Chiara Riganti
Journal:  J Cereb Blood Flow Metab       Date:  2014-06-04       Impact factor: 6.200

7.  Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

Authors:  A H Schinkel; J J Smit; O van Tellingen; J H Beijnen; E Wagenaar; L van Deemter; C A Mol; M A van der Valk; E C Robanus-Maandag; H P te Riele
Journal:  Cell       Date:  1994-05-20       Impact factor: 41.582
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.