Literature DB >> 24896566

Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?

Be'eri Niego1, Robert L Medcalf1.   

Abstract

Plasmin, the principal downstream product of tissue-type plasminogen activator (tPA), is known for its potent fibrin-degrading capacity but is also recognized for many non-fibrinolytic activities. Curiously, plasmin has not been conclusively linked to blood-brain barrier (BBB) disruption during recombinant tPA (rtPA)-induced thrombolysis in ischemic stroke. This is surprising given the substantial involvement of tPA in the modulation of BBB permeability and the co-existence of tPA and plasminogen in both blood and brain throughout the ischemic event. Here, we review the work that argues a role for plasmin together with endogenous tPA or rtPA in BBB alteration, presenting the overall controversy around the topic yet creating a rational case for an involvement of plasmin in this process.

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Year:  2014        PMID： 24896566      PMCID： PMC4126105          DOI： 10.1038/jcbfm.2014.99

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  153 in total

1.  Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation.

Authors:  Maithili Sashindranath; Andre Laval Samson; Catherine Eliza Downes; Peter John Crack; Andrew John Lawrence; Qiao-Xin Li; Ashley Quan Ping Ng; Nigel Charles Jones; Jessica Jade Farrugia; Eman Abdella; Jean-Dominique Vassalli; Rime Madani; Robert Lindsay Medcalf
Journal:  Lab Invest       Date:  2011-04-25       Impact factor: 5.662

Review 2.  The plasminogen activator/plasmin system.

Authors:  J D Vassalli; A P Sappino; D Belin
Journal:  J Clin Invest       Date:  1991-10       Impact factor: 14.808

3.  t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes.

Authors:  Be'eri Niego; Roxann Freeman; Till B Puschmann; Ann M Turnley; Robert L Medcalf
Journal:  Blood       Date:  2012-01-19       Impact factor: 22.113

4.  Plasminogen activator in the rodent brain.

Authors:  H Soreq; R Miskin
Journal:  Brain Res       Date:  1981-07-20       Impact factor: 3.252

5.  Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis.

Authors:  Karim Benchenane; Vincent Berezowski; Carine Ali; Mónica Fernández-Monreal; José P López-Atalaya; Julien Brillault; Julien Chuquet; André Nouvelot; Eric T MacKenzie; Guojun Bu; Roméo Cecchelli; Omar Touzani; Denis Vivien
Journal:  Circulation       Date:  2005-04-25       Impact factor: 29.690

6.  Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group.

Authors: 
Journal:  Stroke       Date:  1997-11       Impact factor: 7.914

7.  Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats.

Authors:  Shinji Fujimoto; Hiroshi Katsuki; Masatoshi Ohnishi; Mikako Takagi; Toshiaki Kume; Akinori Akaike
Journal:  J Cereb Blood Flow Metab       Date:  2007-10-17       Impact factor: 6.200

Review 8.  Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia.

Authors:  Gary A Rosenberg; Yi Yang
Journal:  Neurosurg Focus       Date:  2007-05-15       Impact factor: 4.047

Review 9.  Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update.

Authors:  L Derex; N Nighoghossian
Journal:  J Neurol Neurosurg Psychiatry       Date:  2008-01-25       Impact factor: 10.154

10.  Symptomatic hemorrhage after alteplase therapy not due to silent ischemia.

Authors:  M D Hill; P A Barber; A M Demchuk; R J Sevick; R Frayne; A M Buchan
Journal:  BMC Neurol       Date:  2001-12-18       Impact factor: 2.474
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  36 in total

1.  Basement membrane and stroke.

Authors:  Yao Yao
Journal:  J Cereb Blood Flow Metab       Date:  2018-09-18       Impact factor: 6.200

2.  Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model.

Authors:  Peng Yang; Anatol Manaenko; Feng Xu; Liyan Miao; Gaiqing Wang; Xuezhen Hu; Zhen-Ni Guo; Qin Hu; Richard E Hartman; William J Pearce; Andre Obenaus; John H Zhang; Gang Chen; Jiping Tang
Journal:  Exp Neurol       Date:  2016-06-11       Impact factor: 5.330

Review 3.  2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

Authors:  John H Griffin; Laurent O Mosnier; José A Fernández; Berislav V Zlokovic
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-10-06       Impact factor: 8.311

4.  Regulation of Dipeptidyl Peptidase IV in the Post-stroke Rat Brain and In Vitro Ischemia: Implications for Chemokine-Mediated Neural Progenitor Cell Migration and Angiogenesis.

Authors:  Umadevi V Wesley; James F Hatcher; Emine R Ayvaci; Abby Klemp; Robert J Dempsey
Journal:  Mol Neurobiol       Date:  2016-08-15       Impact factor: 5.590

5.  Reperfusion facilitates reversible disruption of the human blood-brain barrier following acute ischaemic stroke.

Authors:  Chang Liu; Sheng Zhang; Shenqiang Yan; Ruiting Zhang; Feina Shi; Xinfa Ding; Mark Parsons; Min Lou
Journal:  Eur Radiol       Date:  2017-08-30       Impact factor: 5.315

6.  Recombinant tissue-type plasminogen activator transiently enhances blood-brain barrier permeability during cerebral ischemia through vascular endothelial growth factor-mediated endothelial endocytosis in mice.

Authors:  Yasuhiro Suzuki; Nobuo Nagai; Kasumi Yamakawa; Yoshinori Muranaka; Kazuya Hokamura; Kazuo Umemura
Journal:  J Cereb Blood Flow Metab       Date:  2015-07-29       Impact factor: 6.200

7.  Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.

Authors:  Peng Yang; Jiang Wu; Liyan Miao; Anatol Manaenko; Nathanael Matei; Yang Zhang; Liang Xu; William J Pearce; Richard E Hartman; Andre Obenaus; John H Zhang; Feng Xu; Jiping Tang
Journal:  Crit Care Med       Date:  2016-06       Impact factor: 7.598

Review 8.  Engineered microparticles and nanoparticles for fibrinolysis.

Authors:  Dante Disharoon; David W M Marr; Keith B Neeves
Journal:  J Thromb Haemost       Date:  2019-10-07       Impact factor: 5.824

9.  Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.

Authors:  S Singh; A K Houng; D Wang; G L Reed
Journal:  J Thromb Haemost       Date:  2016-08-06       Impact factor: 5.824

10.  Matrix Metalloproteinase-9 Expression is Enhanced by Ischemia and Tissue Plasminogen Activator and Induces Hemorrhage, Disability and Mortality in Experimental Stroke.

Authors:  Sofiyan Saleem; Dong Wang; Tieqiang Zhao; Ryan D Sullivan; Guy L Reed
Journal:  Neuroscience       Date:  2021-01-17       Impact factor: 3.590
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