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Literature DB >> 24896323

The role of the ubiquitin-proteasome pathway in cancer development and treatment.

Fangbao Ding¹, Haibo Xiao¹, Mingsong Wang¹, Xiao Xie¹, Fengqing Hu¹.

Abstract

Ubiquitination is a post-translational modification that plays a role in several cellular processes including cell cycle progression, cell proliferation, DNA replication and apoptosis. Ubiquitin-mediated signaling is frequently altered in cancer cells. Several tumor suppressors and oncogenes interact with enzymes of the ubiquitin-proteasome pathway that function in ubiquitin conjugation and deconjugation. Increasing evidence indicates that the ubiquitin-proteasome system (UPS) plays an important role in cancer development. Several small molecule inhibitors of the UPS have been applied to the treatment of cancer. The current review focuses on the role of the UPS in cancer development and the development of UPS inhibitors for cancer treatment.

Entities: Chemical

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Year: 2014 PMID： 24896323 DOI： 10.2741/4254

Source DB: PubMed Journal: Front Biosci (Landmark Ed) ISSN： 2768-6698

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Cited

19 in total

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The role of the ubiquitin-proteasome pathway in cancer development and treatment.

Review 1. State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research.

2. Downregulation of ring-finger protein 43 in glioma associates with poor prognosis.

3. Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes.

4. Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer.

5. IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation.

6. UBE2O Promotes Progression and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

7. Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.

Review 8. Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity.

9. In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma.

Review 10. The emerging role for Cullin 4 family of E3 ligases in tumorigenesis.